Preclinical Lacunar Stroke Research Services
Lacunar strokes are small strokes that occur in the subcortical areas of the brain, as a result of occlusion of single penetrating arteries. The lacunar hypothesis proposes that the primary mechanisms driving lacunar strokes involve microatheroma and lipohyalinosis. However, the exact etiology remains unclear, and further research is needed to deepen our understanding of this disease.
Fig. 1 Illustration of a coronal brain section with parenchymal findings of cerebral small vessel disease. (Regenhardt, et al., 2019)
As a leading provider of lacunar stroke research services, Ace Therapeutics is committed to helping clients better understand the precise mechanisms of lacunar stroke, particularly by elucidating the small-vessel pathology characterized by abnormal endothelial architecture and fibrosis. We also help our clients develop novel therapeutics for lacunar stroke.
Analysis of the Pathological Mechanisms of Lacunar Stroke
Ace Therapeutics assists clients in exploring the underlying pathogenesis of lacunar stroke, focusing on mechanisms such as lipohyalinosis, atherosclerosis, and cardioembolism.
| Technical Methods | Service Contents |
|---|---|
| Magnetic resonance imaging (MRI) |
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| Vascular imaging | Analyze the mechanism of a lacunar infarct by irregularities or stenosis on intracranial vessel imaging at the site where the perforating branch supplying the infarct originates. |
| Vessel wall imaging (VWI) | Offer VWI to help our clients analyze MCA atherosclerotic plaques in lacunar stroke, which helps to differentiate between lipohyalinosis and perforator origin atherosclerosis. |
Development of Drugs for Lacunar Stroke
Leveraging our unparalleled expertise in brain imaging studies, comprehensive assessments, and customized preclinical models, Ace Therapeutics can help you develop a wide range of drugs for the treatment of lacunar stroke, such as antithrombotic agents. We are committed to advancing preclinical drug development for lacunar stroke.
Ace Therapeutics actively works with researchers and pharmaceutical companies dedicated to ischemic stroke research. With our extensive experience and specialized models, we can provide a comprehensive and customized approach to the preclinical development of lacunar stroke therapeutics. Please contact us to learn more.
- Yaghi, S., et al. (2021). Lacunar stroke: mechanisms and therapeutic implications. Journal of Neurology, Neurosurgery & Psychiatry, 92(8), 823-830.
- Regenhardt, R. W., et al. (2019). Pathophysiology of lacunar stroke: history's mysteries and modern interpretations. Journal of Stroke and Cerebrovascular Diseases, 28(8), 2079-2097.
