Cerebral Blood Flow Monitoring Service in Animal Models of Stroke

Most strokes are intrinsically ischemic, which means that they are caused by vascular obstruction leading to disruption of cerebral blood flow (CBF). CBF disruption affects the region of the lesion, homologous sites in the contralateral hemisphere, and even remote regions usually associated with the site of injury. Therefore, CBF monitoring is of great importance in stroke research and is an important tool for the preparation and validation of animal models of stroke. CBF functional mapping is widely used to monitor hemodynamic changes in the healthy brain as well as changes associated with cerebrovascular disease.

Fig. 1. Representative LSCI imaging of cerebral cortical blood flow monitoring at different time points. (Aswendt et al., 2014)

Our CBF Monitoring Service in Animal Models of Stroke

Ace Therapeutics can measure CBF in animal stroke models. Our service combines a range of cutting-edge monitoring methods to ensure accurate and reliable data collection. CBF monitoring is widely used in preclinical studies of stroke, where changes in cerebral blood flow can be reflected in pathophysiological states.

The main technologies used in our CBF monitoring service include:

• Laser Doppler Flowmetry (LDF)
• Magnetic Resonance Imaging (MRI)
• Laser Speckle Contrast Imaging (LSCI)
• Functional Ultrasound Imaging
• Micro-computed Tomography (Micro-CT) Imaging
• Positron Emission Tomography (PET) Imaging
• Single-photon Emission Computed Tomography (SPECT) Imaging

To ensure the success and reliability of our CBF monitoring services, we carefully select the most appropriate methodology based on the experimental requirements, the species under study, and the modeling technique. Our team of highly skilled experts works closely with researchers to customize CBF monitoring protocols, taking into account factors such as cost-effectiveness and convenience.

Applications of CBF Monitoring in Animal Models of Stroke

• Can objectively assess the occlusion or recanalization of cerebral arteries
• Can determine the duration of ischemia
• Can be used as a direct reference for changes in cerebral hemodynamics
• Allows timely assessment of the success of the model and confirmation of the validity and reliability of the experimental results
• To study the pathophysiology of stroke and evaluate therapeutic interventions

Why Choose Us

• Our service utilizes a range of advanced CBF monitoring technologies to ensure accurate and reliable measurement of cerebral hemodynamics.
• We can tailor CBF monitoring protocols to specific experimental needs, species, and modeling approaches.
• Our experienced team of neuroscientists provides a comprehensive analysis of CBF data and ongoing support throughout the study.
• By incorporating CBF monitoring into animal stroke models, researchers can validate the success of the model, monitor the duration of ischemia, and ensure the integrity of experimental results.

Ace Therapeutics's CBF monitoring service provides researchers with a comprehensive, state-of-the-art approach to the study of stroke. Accelerate your stroke research by partnering with Ace Therapeutics. If you are interested in our services, please do not hesitate to contact us!

1. Yin, L., et al. (2022). Laser speckle contrast imaging for blood flow monitoring in predicting outcomes after cerebral ischemia-reperfusion injury in mice. BMC neuroscience, 23(1), 1-7.