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- ADME/DMPKDrug Efficacy Testing
- Cerebral Infarct Size Measurement
- Histological Assessment
- Physiological Monitoring
- Behavioral TestingBrain Imaging
- Cerebral Blood Flow Monitoring
- Brain Edema Measurement
- Assessment of Blood-Brain Barrier
- Assessment of Leukocyte-Platelet Aggregates
- Quantitative Analysis of Protein and mRNA Expression
Safety AssessmentIn Vitro Pharmacology- Cell Viability Assay
- Caspase-3 Activity Assay
- In Vitro Neuroinflammatory Models and Assays
- Excitotoxicity In Vitro Assay
- Cell-Based Mitochondrial Function Assay
- In Vitro Oxidative Stress Assay
- Ischemia-Triggered Glutamate Excitotoxicity
- NMDA Receptor-mediated Excitotoxicity
- AMPA Receptor-mediated Excitotoxicity
Molecular Mechanism of Oxidative StressNeuroinflammatory Mechanisms- Ischemia-Reperfusion Injury
Cell Death Mechanism- Autophagy MechanismApoptotic Mechanism
- Ferroptosis Pathways
- Necroptosis Signaling Pathways
Epigenetic Mechanism- Gut Microbiota
- Animal Modeling of Stroke
- Animal Modeling of Ischemic StrokeAnimal Modeling of Hemorrhagic StrokeIn Vitro Modeling of Stroke
- In Vitro Modeling of Ischemic Stroke
- In Vitro Modeling of Hemorrhagic Stroke
- Small-Molecule Antiplatelet DrugsNeuroprotective PeptidesMonoclonal Antibodies for StrokeStem Cell-Based Therapies for StrokeDrug Delivery SystemsInquiry
Development of Stem Cell-Based Therapy for Stroke
Due to the limitations of existing treatments, new stroke therapies are needed. Stem cells have the ability to proliferate, self-renew and differentiate into various functional cells under certain conditions. Currently, many studies are devoted to investigating the great potential of stem cells in the treatment of various diseases. A large number of these studies have been conducted on the use of various types of stem cells for the treatment of ischemic stroke. Stem cell-based therapies for stroke aim to promote neurogenesis and replace lost neurons or protect surviving neurons to improve neurological recovery. Bone marrow stem cells (BMSCs) and mesenchymal stem cells (MSCs) have been shown to have immunomodulatory properties that inhibit post-stroke inflammation and potentially improve recovery.
Fig. 1. Mechanisms of action of Mesenchymal Stem Cells in treating stroke. (Singh et al., 2020)Our Services
As a a stroke-focused CRO, Ace Therapeutics is dedicated to helping clients develop stem cell-based therapies for stroke to reduce neuroinflammation and regenerate damaged brain tissue and nerve cells lost due to stroke. Our multidisciplinary team of experts includes neuroscientists, cell biologists, and biomedical engineers, who work closely with clients to design and implement customized preclinical studies of stem cell-based therapies for stroke.
Development of Stem Cell-Based Therapy
We offer several types of stem cells, such as neural stem cells, BMSCs, MSCs, for extensive basic and translational research to develop stem cell therapies for stroke. Our advanced cell processing facility ensures consistent quality and purity of stem cells to meet the stringent requirements of preclinical applications.
Pre-Clinical Studies of Stem Cell-Based Therapy for Stroke
We provide a series of in vitro and animal models of stroke to rigorously evaluate the safety and efficacy of various types of stem cells in the treatment of neurological disorders, including ischemic brain injury, acute ischemic stroke, hemorrhagic stroke, and chronic stroke.
We explore the applications of stem cells in terms of various parameters such as types of stem cell , stem cell dose, route of administration, and stem cell homing and tracking.
- Comprehensive behavioral assessment to measure improvements in motor, sensory, and cognitive function.
- Histological analysis of the infarcted area of the brain.
- Magnetic resonance imaging (MRI) to detect small changes in brain tissue.
- Functional magnetic resonance imaging (fMRI) to identify specific locations in the brain where certain functions (such as speech or memory) occur.
- Cerebral blood flow tests to measure the amount of oxygen in the blood supply that reaches different areas of the brain.
Stem Cell Modification Strategies
We offer advanced modification technologies to help clients optimize the targeting, implantation, and integration of stem cells into damaged brain tissue to enhance their ability to treat stroke.
Genetic Modification of Stem Cells Transfection of stem cells to enhance their vascular regenerative capacity, therapeutic function and homing ability Nanoparticle Modification of Stem Cells Utilizing various nanoparticles to enhance the therapeutic capabilities of stem cells and to track their behavior in vivo Biomaterial Modification of Stem Cells Using peptides, hydrogels, and lipid microcapsules to enhance the homing or survival of stem cells in ischemic areas Pretreatment of Stem Cells 3D stem cell culture Ace Therapeutics is committed to helping our clients accelerate the development of stem cell-based therapies for stroke. Our team works with academic and pharmaceutical partners to design and conduct well-controlled preclinical studies. Please contact us for further information. We look forward to working with you!
Reference- Singh, M., et al. (2020). Application of stem cells in stroke: a multifactorial approach. Frontiers in Neuroscience, 14, 532599.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
Ace Therapeutics is a global leading provider of stroke research services. We are committed to accelerating progress in stroke research and drug development.
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