Ace Therapeutics is committed to advancing your psychiatric research program through high-quality preclinical anxiety research and development services. With state-of-the-art animal models and tests, we can provide comprehensive anxiety disorder-related mechanism of action studies, preclinical efficacy, safety and toxicology evaluations of anxiolytic drugs, thereby facilitating the development of innovative therapeutic approaches. Our services are designed to help you provide comprehensive technical support in the development of anxiety disorders and related drugs, reduce development costs and shorten development time.

Treatment of Anxiety Disorder

Anxiety disorder can lead to severe anxiety, self-consciousness, and embarrassment in everyday interactions. Anxiety disorder creates fear and anxiety that can lead to avoidance, which can disrupt your life. In addition, other anxiety disorders and certain other mental illnesses (especially major depressive disorder and substance abuse problems) often occur in conjunction with social anxiety disorder. If left untreated, social anxiety disorder can affect your life. The most common approaches to treating social anxiety disorder include psychotherapy or medication, or a combination of both.

Current Status of Research on Anti-social Anxiety Drugs

Anti-anxiety medications have been studied for many years, but to date there is no perfect medication option. Selective serotonin reuptake inhibitors (SSRIs) are often the medication of choice for the treatment of persistent social anxiety symptoms. 5-hydroxytryptamine and norepinephrine reuptake inhibitors (SNRIs) are also options for the treatment of social anxiety disorders. Benzodiazepines may have a calming effect on anxiety symptoms. beta-receptor antagonists may reduce the body's anxiety response. However, these drugs have greater side effects, such as insomnia, sexual dysfunction, and headache, and do not completely cure social phobia.

Key Targets for Anti-Anxiety Drug Development

• GABA-A receptor
• SERT
• DRDs
• D2 receptor
• HT1A receptor
• ADRA2
• NET
• MAO-A
• MTNR1A

How Can We Help?

Pathophysiologic Mechanism Research Services of Anxiety

Our anxiety-related mechanism of action research services provide a comprehensive exploration, from the molecular to the behavioral level, to provide insight into the biological nature of anxiety disorders and the pathways of pharmacological intervention. We use advanced molecular biotechnology, cell culture, animal models and behavioral assessments to reveal key neurobiological pathways and investigate how drugs modulate these pathways to alleviate anxiety symptoms. In addition, we provide research and technical support for personalized medical strategies aimed at bringing innovative solutions to the treatment of anxiety disorders.

Preclinical Screening and Evaluation Services for Anti-Anxiety Drugs

Ace Therapeutics' preclinical drug development for antisocial anxiety disorder includes the following:

• Screening: We can help you screen candidate compounds with potential anti-social anxiety disorder activity from a large number of compounds or natural products through chemical synthesis, natural products from screening or computer simulation.
• In vitro evaluation: We can perform in vitro testing of screened candidate compounds to evaluate their efficacy and toxicity in cellular models.
• Animal model evaluation: We can evaluate the efficacy of candidate compounds in animal models by behavioral analysis, imaging analysis, and histological analysis.
• Pharmacokinetic (PK) studies: We can evaluate the pharmacokinetic characteristics of candidate compounds in animals such as mice, rats and dogs, such as absorption, distribution, metabolism, and excretion.
• Safety assessment: We can evaluate the safety of candidate compounds at different doses to assess their toxicity and side effects on the organism.

Related Services

• Social Anxiety Disorder Animal Models
• Anxiety Behavior Tests
• Histological Analysis in Psychiatry
• Preclinical Imaging Services in Psychiatry
• Antipsychotics Screening Services
• Antipsychotic Discovery and Preresearch Services
• Pharmacokinetics Analysis Services for Antipsychotics

Ace Therapeutics can provide chemical synthesis, analysis, toxicological evaluation, and all preclinical studies for antipsychotic drugs. These services are designed to help you provide comprehensive technical support, reduce development costs, and shorten development time during the development of new drugs. If you are interested in our services, please contact us to learn how we can support you in your project.