Anxiety Behavior Tests

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Ace Therapeutics has developed various behavioral tests to assess different types of anxiety. Experimental animals are placed in a series of stressful situations that produce emotional disorders. We apply specific tools to test the behavioral and physiological indicators of experimental animals, providing researchers with effective methods to explore the in-depth mechanisms of emotional disorders and identify and screen anti-anxiety drugs.

Introduction of Anxiety Behavior Tests

Anxiety is a medical condition related to our mental and physical behavior, with many cognitive, affective, behavioral and physical characteristics. There are four types of anxiety: generalized anxiety disorder, specific phobia, social anxiety disorder, and panic disorder. There are two other conditions that also present with anxiety disorders, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD). Rodent-based behavioral tests and models are widely used to understand the mechanisms by which stress triggers anxiety-related behaviors and to identify new approaches to treating anxiety-related disorders.

Fig. 1 Classification of anxiety disorder. (Himanshu, et al., 2020)

Anxiety Behavior Testing Services

Ace Therapeutics offers a variety of classic anxiety behavior testing experiments. These tests play an important role in exploring the mechanisms of anxiety and anti-anxiety drugs, allowing research to better predict clinical outcomes in humans, improving the success of clinical trials, and accelerating the development of new treatments. Anxiety behavior tests that we offer include but are not limited to the following:

Behavioral tests	Animals used	Response to be observed	Inference of the observation	Types of anxiety can be evaluated
Elevated plus maze	Mice, Rats, Gerbils	Change in entries and time spend in open arm	If increase: drug shows its anxiolytic effect If decrease: drug does not have anxiolytic effect	Generalized anxiety disorder, specific phobias, PTSD
The light and dark box	Mice and Rats	Change in entries and time spent in light box	If increase: drug shows its anxiolytic effect If decrease: drug does not have anxiolytic effect	Generalized anxiety disorder, specific phobias
Marble burying behavior model	Mice and Rats	Change in the number of marbles buried	If increase: drug does not have anxiolytic effect If decrease: drug shows its anxiolytic effect	OCD
The hole board model	Mice and Rats	Change in locomotory, head dipping and head rearing behavior	If increase: drug shows its anxiolytic effect If decrease: drug does not have anxiolytic effect	Generalized anxiety, specific phobias, social anxiety disorder, panic disorder
The open-field test	Mice and Rats	Change in locomotory, Rearing, time spent moving, distance moved and change in activity over time	If time spent in centre part is more than time spent in perimeter than drugs consider as anxiolytic	Generalized anxiety disorder, specific phobias, and panic disorder

Applications of Anxiety Behavior Tests

Anxiety-related diseases and drug mechanism research.
Research on the mechanism of action of anti-anxiety drugs.
Screening and efficacy evaluation of anti-anxiety drugs.

Ace Therapeutics selects the appropriate anxiety behavior testing method according to your research needs and provides high-quality testing services for your research. If you are interested, please make an inquiry with a description of your specific research and we will be happy to assist you.

Reference

Himanshu; Dharmila, Sarkar D; Nutan. A Review of Behavioral Tests to Evaluate Different Types of Anxiety and Anti-anxiety Effects. Clin Psychopharmacol Neurosci. 2020, 18(3):341-351.

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