Pharmacokinetic Profiling Services of Antipsychotics

Pharmacokinetic Profiling Services of Antipsychotics

Inquiry

Pharmacokinetic analysis helps to improve the success rate of antipsychotic drug development. Ace Therapeutics utilizes our ADME platform, in vivo PK platform to study a variety of potential antipsychotics, providing our clients with the basic pharmacokinetic parameters of the drug and studying the nature and characteristics of drug absorption, distribution, metabolism and excretion. Our high-quality services and reliable data can meet the different needs of the antipsychotic drug development stage, thus accelerating your antipsychotic drug development program.

Our Pharmacokinetic Profiling Services of Antipsychotics

ADME Profiling Services of Antipsychotics

Ace Therapeutics' ADME analytical platform enables clients to gain comprehensive insight into the absorption, distribution, excretion, and metabolic properties of their antipsychotic drug candidates. Our team of experienced experts utilizes highly sensitive LC-MS/MS, metabolite characterization, and other technologies to provide you with accurate and reliable analytical results. We are dedicated to providing tailored analytical solutions to meet your needs at each stage of drug development.

Drug Interactions Assessment Services of Antipsychotics

Ace Therapeutics offers comprehensive drug interaction assessment services to help clients identify factors that may affect drug disposition. Our services begin with in vitro experiments and continue with the elucidation of potential DDI mechanisms and the obtaining of kinetic parameters for further study.

Our Pharmacokinetic Profiling Strategies

  • In vitro pharmacokinetic profiling

Ace Therapeutics offers in vitro pharmacokinetic study services that can be used as an important tool for screening potential drug candidates. Our high throughput screening platform can facilitate lead discovery and optimization, helping drug developers understand compound properties as quickly as possible to accelerate access to candidates. Our ADME screening services can provide customized solutions to meet the specific project needs of various clients. Specific services include, but are not limited to:

  • In vivo pharmacokinetic profiling

During drug development, it is critical to understand the pharmacokinetic properties of drugs such as metabolism, absorption, distribution and excretion in vivo. We offer various in vivo pharmacokinetic studies, tissue distribution studies in rodents, including but not limited to the following:

  • Drug concentration determination: by collecting animal samples (e.g., blood, cerebrospinal fluid, or tissue samples) and determining the concentration of the drug in various biological matrices.
  • Determination of pharmacokinetic parameters: Based on drug concentration data, pharmacokinetic parameters such as drug clearance rate, volume of distribution and drug half-life are calculated.
  • Drug metabolism studies: to understand the metabolic activity and metabolic pathways of drugs by analyzing metabolites in samples such as feces, urine, and bile.
  • Drug interactions study.

Our Capabilities

Ace Therapeutics can help design and customize the best pharmacokinetic study protocol to fit your antipsychotics discovery program. We can examine multiple parameters, including detailed information about the route, the concentration of administration, timing, etc., to ensure the success of your post-renewal study. In addition, we offer a range of analytical support including

We can analyze a variety of neurotransmitters in the extracellular space of the rodent brain through conventional microdialysis. By combining microdialysis with sensitive bioanalytical techniques to provide the most comprehensive information, we help you understand the dynamics of molecular concentrations involved in intercellular communication and metabolism in awake, freely moving animals.

We offer true quantitative dialysis through our MetaQuant probes, which can be used for multiple aspects of the antipsychotic drug development process, including drug metabolism, potency, toxicity, structure, and activity studies.

We offer a push-pull microdialysis technique for the collection of macromolecules. We combine this technique with immunoassays for measuring dynamic changes in peptides, proteins, and other macromolecules such as α-synuclein, Tau, and cytokines.

We can customize assays by combining PK or PD microdialysis techniques or by combining microdialysis with other methods, such as behavioral or EEG measurements. We can perform real-time measurements of pharmacodynamic changes in neurotransmitters, modulators, and proteins through a multi-probe approach while collecting free drug concentrations to establish an accurate PK/PD relationship.

Our Service Process

Ace Therapeutics is dedicated to providing clients with customized and comprehensive pharmacokinetic analysis services. These services help clients obtain key pharmacokinetic parameters and information to support antipsychotic dosage optimization, dosing regimen development, and drug development decisions.

  • Project assessment
  • Customized experimental design
  • In vivo and in vitro pharmacokinetic analysis
  • Data analysis
  • Delivery of results

Ace Therapeutics' team of experts and state-of-the-art equipment ensures high-quality data and accurate interpretation of results to provide scientific support for your antipsychotic drug development. Please contact us for more details and we will be happy to assist you.


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