Ace Therapeutics provides specialized preclinical research and development services for OCD. Our comprehensive solutions cover the entire process from pathogenesis to drug screening and efficacy evaluation. With precise animal models and advanced experimental techniques, we are committed to helping our clients rapidly identify potential therapeutic molecules and accurately assess their efficacy and safety, thus making progress in OCD research and drug development.

What Medications Can Help Treat Obsessive-Compulsive Disorder?

Medications used to treat OCD include selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, antipsychotics, and benzodiazepines.

Selective serotonin reuptake inhibitors (SSRIs) are the first-line drugs for OCD, including fluoxetine, paroxetine, and sertraline, which have a good effect on relieving and improving obsessive-compulsive symptoms. Tricyclic antidepressants such as promethazine and amitriptyline are also often used to treat OCD, but have more side effects and should be used with caution.

How Can We Help?

Pathophysiology of Obsessive-Compulsive Disorder Research Service

The pathophysiological mechanisms of OCD are not fully understood, but there have been some studies suggesting that OCD is related to neuronal connectivity, brain structure, and neurotransmitters.

• Neuronal connectivity: Neuronal connectivity is achieved through synapses, where specific transmitters (e.g., serotonin) are released at synapses to transmit information through communication between neurons. Some studies have shown that in people with OCD, certain synapses do not work properly, resulting in poor information transfer between neurons, which leads to obsessive-compulsive symptoms.
• Brain structure: Parts of the human brain are thought to be involved in OCD, specifically the basal ganglia. The basal ganglia is the part of the brain responsible for controlling motor and cognitive functions, which also includes thinking, decision-making and behavior. Studies have shown that the basal ganglia are associated with OCD and may cause people to repeat specific behaviors, thoughts or objects over and over again.
• Neurotransmitters: Neurotransmitters are chemicals that are transmitted through neurons. Several studies have shown that low serotonin and dopamine levels are associated with OCD. Low serotonin levels can cause people to be depressed, and dopamine is associated with reward and surprise, which can lead to repeated repetition of certain behaviors.

Ace Therapeutics provides clients with comprehensive research services on the pathophysiologic mechanisms of OCD. Through the integration of neuroimaging techniques, genetic analysis, neurophysiological testing, and biomarker detection, Ace Therapeutics explores the neurobiological basis of OCD. Our services are aimed at accelerating the understanding of OCD pathogenesis, promoting the translation from basic research to clinical application, and helping our clients make breakthroughs in the treatment of OCD.

Preclinical Screening and Evaluation Services for OCD Therapeutic Drugs

Ace Therapeutics provides preclinical drug development services for the treatment of OCD, including basic research, chemical drug design, and optimization and validation of cellular and animal models.

• Identifying the neurons and neurotransmitters that cause OCD
• The pathogenesis of OCD is linked to abnormalities in neurons and neurotransmitters, and we can help you identify the neurons and neurotransmitters that cause the disorder so that you can design targeted medications.
• Validate potential targets
• Based on studies of neurons and neurotransmitters, we need to further validate possible targets, such as serotonin, glutamate, GABA, selective 5-hydroxytryptamine reuptake inhibitors, etc.
• Development of effective cellular and animal models
• To better study and test drugs, we can help you develop effective cellular and animal models, such as using gene editing techniques to modify mouse genes, construct more realistic neural circuits, etc.
• Discover novel compounds
• Developing novel compounds is also one of the important aspects of preclinical drug development. We are able to find suitable compounds for better therapeutic effects through computer simulations, chemical synthesis and other methods.

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Ace Therapeutics is committed to providing technical support for your understanding of the mechanisms and treatments for psychiatric disorders. If you are interested in our services, please contact us to learn how we can support you in your project.