Psoriasis Model Development Services

At Ace Therapeutics, we specialize in the development of advanced psoriasis models to support drug discovery and therapeutic advancements. Our comprehensive approach integrates both in vitro and in vivo models to provide a robust platform for understanding psoriasis pathophysiology and evaluating potential treatments.

Significance of Psoriasis Models

Psoriasis is characterized by the development of red, scaly plaques on the skin, often accompanied by intense itching and discomfort. Despite significant advancements in medical research, the underlying mechanisms driving the pathogenesis of psoriasis remain complex and multifaceted, posing significant obstacles to the development of novel therapeutic interventions. To address this challenge, researchers and pharmaceutical companies are increasingly relying on sophisticated preclinical models that can faithfully replicate the hallmarks of psoriasis. These models serve as invaluable tools for elucidating disease pathways, identifying potential drug targets, and evaluating the efficacy and safety of candidate therapeutics.

Custom Psoriasis Models

To address these challenges, Ace Therapeutics offers a comprehensive suite of in vitro and in vivo psoriasis model development services, providing researchers and pharmaceutical companies with the tools they need to accelerate their research and drive innovation.

In Vitro Psoriasis Model Development

By stimulating human primary keratinocytes with a carefully selected cocktail of pro-inflammatory cytokines, we are able to induce a psoriasis-like phenotype. This model provides a valuable platform for investigating the effects of potential therapeutic agents on the inflammatory response at the gene and protein expression levels.

Comprehensive Cell-Based Assays: Employing a variety of cell types including primary human keratinocytes, co-culture systems with immune cells, and immortalized cell lines, we are able to support high-throughput screening and in-depth mechanistic studies. Customized Model Development: Our team of experienced researchers can work closely with you to develop custom 2D monolayer cultures or 3D skin equivalents that mimic the specific features of psoriasis that are most relevant to your research objectives.

In Vivo Psoriasis Model Development

Our in vivo model development services encompass a range of models to recapitulates the hallmarks of acute psoriasis, facilitating the evaluation of potential therapeutics in a more physiological context. We can analyze the histopathological changes in the epidermis and dermis, as well as the phenotypic profile of the immune cells involved in the disease process.

Imiquimod-Induced Psoriasis Models: Inducing psoriasis-like symptoms using topical imiquimod application. IL-23-Induced Psoriasis Models: Utilizing IL-23 to drive the inflammatory response and skin lesions. Mannan-Induced Psoriatic Arthritis Models: Investigating both skin and joint manifestations of the disease.

Our Advantages in Psoriasis Model Development

At Ace Therapeutics, we pride ourselves on our ability to provide comprehensive preclinical solutions that accelerate the development of novel psoriasis therapies.

• Comprehensive Analytical Capabilities: Leveraging imaging techniques, flow cytometry, laser capture microdissection, and multiplexed cytokine profiling, we provide our partners with in-depth insights into the molecular and cellular mechanisms underlying psoriasis.
• Expertise and Tailored Services: Our team of seasoned scientists and subject matter experts work closely with our partners, offering personalized guidance and tailored solutions to address their specific research needs.

Ace Therapeutics is dedicated to partnering with researchers and pharmaceutical companies to advance the frontiers of psoriasis research. If you are interested in our psoriasis model development services or would like to explore how our models can enhance your research, please contact us to initiate a discussion. Our dedicated team is here to work with you and help navigate the complexities of this skin disease.