In Vivo Psoriasis Model Development Services
At Ace Therapeutics, we understand the critical importance of preclinical evaluation in the development of effective psoriasis therapies. Our dedicated team of scientists harnesses the latest advancements in immunology and genetic engineering to develop a suite of in vivo psoriasis models that faithfully recapitulate the complex pathological features of this chronic, immune-mediated skin disease.
Overview of In Vivo Psoriasis Model Development
In vivo psoriasis models are essential research tools for studying this chronic inflammatory skin disease and evaluating potential therapies. These animal models aim to recapitulate the hallmarks of human psoriasis, such as epidermal thickening, immune cell infiltration, and dysregulated cytokine production. Commonly used approaches include xenografts with human psoriatic skin, chemically-induced psoriasiform dermatitis in mice, and genetically-engineered mouse strains. These in vivo platforms have enabled critical insights into disease pathogenesis and serve as preclinical screening tools for novel therapeutic candidates.
Fig. 1 Use of murine psoriasis models for therapeutic proof-of-principle studies. (Schön MP, et al., 2021)
Custom In Vivo Psoriasis Models
At Ace Therapeutics, we offer a range of specialized services for the development of in vivo psoriasis models. These models are essential for mimicking the human condition and assessing the efficacy of potential therapies.
| Service Options | Methodology | Key Features |
| Imiquimod-Induced Psoriasis Model | Topical application of imiquimod (IMQ) | Recapitulates key hallmarks of human psoriasis Allows for quantification of disease severity using Psoriasis Activity and Severity Index (PASI) |
| IL-23-Induced Psoriasis Model | Intradermal injection of recombinant IL-23 | Models the critical role of the IL-23/Th17 axis in psoriasis pathogenesis Suitable for assessing therapies targeting this inflammatory pathway |
| Mannan-Induced Psoriatic Arthritis Model | Systemic administration of mannan | Utilizes DBA mouse strain susceptible to psoriatic arthritis development Enables evaluation of therapeutics for the treatment of both skin and joint disease |
Humanized Psoriasis Model Development Services
At Ace Therapeutics, we support our clients' research by offering the development of humanized in vivo psoriasis models.
| Service Options | Descriptions |
| Humanized IL-17A/IL-17F Mouse Model | We generate the humanized IL-17A/IL-17F mouse model using gene-editing technology, which allows clients to evaluate the efficacy of therapeutics targeting the human-specific IL-17 cytokines. Given the pivotal role of IL-17 in psoriasis pathogenesis, this model provides clinically relevant data for drug evaluation. |
| Humanized Skin Xenograft Model | We graft human psoriatic skin onto immunodeficient mice to support our clients in assessing the direct impact of their therapeutic candidates on the pathological processes underlying psoriasis. |
Psoriasis Model Evaluation Services
Our services encompass a wide range of evaluation parameters designed to provide a detailed assessment of the disease model and therapeutic efficacy.
| Service Options | Descriptions |
| Skin Thickness Measurement | A critical parameter for monitoring disease progression and treatment effects |
| Erythema and Scaling Assessment | Clinical endpoints that offer a visual representation of skin inflammation |
| Blood Biomarker Analysis | Analysis of circulating cytokines and other biomarkers for a systemic understanding of the immune response |
| In Vivo Imaging Analysis | Utilizing optical coherence tomography (OCT) for non-invasive, real-time monitoring of skin changes |
| Ex Vivo Imaging and Histology Analysis | Employing histology and immunohistochemistry (IHC) to examine tissue sections for histological changes and immune cell infiltration |
Ace Therapeutics is dedicated to advancing the understanding of psoriasis and supporting the development of innovative therapeutic solutions. By offering robust, reliable, and tailored preclinical models, we support the advancement of dermatological research and the development of effective therapies for psoriasis. Our deep scientific expertise and commitment to customization make us the ideal collaborator to advance the understanding of this complex skin disorder. Contact us today to discuss your project requirements and start a collaboration that drives innovation in dermatology.
Reference
- Schön MP, et al. Animal models of psoriasis-highlights and drawbacks. J Allergy Clin Immunol. 2021;147(2):439-455.