Mannan-Induced Psoriatic Arthritis Model Development Services
Reliable and reproducible preclinical models are essential to advancing the understanding of psoriatic arthritis (PsA) and developing effective therapies. As a leading preclinical contract research organization (CRO), Ace Therapeutics offers a comprehensive suite of services to support the development and evaluation of MIP models.
Introduction to MIP Models
PsA is a complex autoimmune condition characterized by chronic inflammation, joint damage, and a range of skin manifestations. To faithfully recapitulate the pathophysiology of this debilitating disease, researchers have developed several in vivo models. Among available animal models of PsA, the mannan-induced psoriatic arthritis model has proven particularly reliable. Mannan, a polysaccharide derived from the cell wall of the yeast Saccharomyces cerevisiae, can induce psoriatic-like skin inflammation and joint involvement in inbred mouse strains.
Fig. 1 Mannan and imiquimod induced experimental plaque psoriasis inflammation in inbred mice. (Wu H, et al., 2023)
MIP Model Development Services
At Ace Therapeutics, we have developed a deep understanding of the MIP model and its applications in preclinical research.
- To establish the MIP model, we utilize the DBA mouse strain, which has been demonstrated to be highly susceptible to the development of the psoriatic arthritis phenotype.
- We perform a single intraperitoneal (IP) injection of mannan, and our extensive dose-finding studies allow us to determine the optimal dose of mannan for consistent disease induction.
Comprehensive Evaluation and Validation of MIP Models
To provide our clients with a detailed understanding of the MIP model, we employ a multi-faceted approach to assess the disease progression and therapeutic response.
| Service Options | Description |
| Macroscopic Scoring | Evaluation of dermatological parameters, such as erythema (redness), scaling, and edema Assessment of arthritic changes in the hindlimbs and toes |
| In Vivo Imaging | Optical coherence tomography (OCT) for high-resolution imaging of skin and joint structures Thermography for the assessment of inflammation and blood flow dynamics |
| Histological Analysis | Detailed examination of skin and joint tissues to characterize the underlying pathological changes |
Our Advantages in MIP Model Development
The model closely mimics the complex interplay between skin and joint involvement, as observed in human psoriatic arthritis, making it a valuable tool for translational research.
Ace Therapeutics' standardized protocols and state-of-the-art facilities ensure consistent and reliable results, allowing for robust data interpretation and confident decision-making.
Compared to other psoriatic arthritis models, the mannan-induced approach is relatively simple, economical, and can be readily adapted to your specific research needs.
Our highly skilled scientists have extensive expertise in preclinical research and a deep understanding of the mannan-induced psoriatic arthritis model, ensuring you receive unparalleled support throughout your project.
The MIP model is a critical tool for preclinical research, enabling a comprehensive evaluation of disease progression and assessment of potential therapeutic interventions. At Ace Therapeutics, we are committed to collaborating with you and delivering tailored solutions that drive your research forward. To learn more about how our MIP model development services can accelerate your drug discovery and development efforts, please do not hesitate to contact us.
Reference
- Wu H, et al. Comparative studies on mannan and imiquimod induced experimental plaque psoriasis inflammation in inbred mice. Clin Exp Immunol. 2023;211(3):288-300.