Purpose of The Ocular Pharmacology Study

The eye is a highly specialized organ affected by a wide range of pathologies. Both local and systemic diseases can affect the function of different eye physiological structures. The least invasive routes of ophthalmic drug administration are topical (e.g., eye drops) and systemic (e.g., tablets) administrations. The efficacy of topical and systemic administration is limited due to physical and biochemical barriers. In vitro ophthalmic pharmacology studies before clinical trials can determine the undesired drug effects of ophthalmic products that may be related to human safety, guide clinical medication, reduce adverse reactions, and design and develop new adaptations for long-term toxicity tests and symptoms for reference.

Fig. 1. Physiological barriers in ocular drug delivery. (Adrianto MF, et al., 2022)

Service Overview

Ocular pharmacology research is a key stage in preclinical ophthalmic product development. Ace Therapeutics has decades of experience in ophthalmic product development. It can assist global customers to advance their ophthalmic product pharmacology research in the most cost-effective way. We provide comprehensive and advanced ocular disease live animal models and drug delivery strategies for ophthalmic product development for global clients.

At Ace Therapeutics, hundreds of non-clinical animal ocular disease models we provide have been professionally validated, each specifically designed to assess the state of ocular disease. In addition, our talented scientists can provide professional advice to guide you to select the most suitable model for in vitro pharmacology research and drug efficacy evaluation.

At Ace Therapeutics, we provide comprehensive and high-quality preclinical drug development services. Our clients benefit from our consulting expertise to expedite the entire drug development process leading to regulatory submission.

According to global customers' project research needs, Ace Therapeutics provides the following preclinical research services for ophthalmic drugs, including but not limited to:

Advantages of Ace Therapeutics' Ocular Pharmacology Study

• Hundreds of validated ocular disease models.
• Extremely low rate of adverse reaction complications.
• A full range of ocular delivery system aids.
• Customized ocular disease models and protocols based on your project needs.
• Multiple advanced detection platforms and complementary services, including optical coherence tomography (OCT), electroretinography (ERG), intraocular pressure measurement (IOP), digital fundus photography and pachymetry (corneal pachymetry).

With strong professional knowledge and an advanced technology platform, Ace Therapeutics provides comprehensive ocular pharmacology study services. Our professional ocular pharmacology study team will evaluate your ophthalmic products by screening the most suitable ocular disease models and delivery systems according to your project needs. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

1. Bucolo C, Toro MD, Eandi CM. Editorial: Ocular Pharmacology: Recent Breakthroughs and Unmet Needs. Front Pharmacol. 2022 Feb 14;13: 848332.
2. Novack GD, Robin AL. Ocular pharmacology. J Clin Pharmacol. 2016 May;56(5):517-27.
3. Adrianto MF, Annuryanti F, Wilson CG, et al. In vitro dissolution testing models of ocular implants for posterior segment drug delivery. Drug Deliv Transl Res. 2022 Jun;12(6):1355-1375.

• Ocular Toxicology Services
• Ocular Pharmacokinetic Services
• Ocular Histology and Histopathology Services
• Customized Non-GLP Ophthalmic Program Development Services
• Customized Services for Ocular Drug Delivery System Development

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