Crohn's Disease Research Services

Crohn's disease (CD) is a chronic, relapsing inflammatory disease of the gastrointestinal (GI) tract. The inflammation in Crohn's disease affects the entire intestinal tract, with the most commonly affected area being the distal ileum. The exact cause of Crohn's disease is unknown, but it is likely to be due to a combination of a dysregulated immune response, altered microbiota (dysbiosis), genetic susceptibility, and environmental factors that lead to disruption of barrier function. There is no known cure, and the disease can be managed through a combination of immunosuppressive medications, dietary changes, or surgery.

Fig. 1. An in-depth understanding of immuno-mediated pathogenesis of Crohn's disease. Fig. 1. Immuno-mediated pathogenesis of Crohn's disease. (Petagna et al., 2020)

Explore Our Expertise in Crohn's Disease

Ace Therapeutics is at the forefront of preclinical Crohn's disease research, combining long-standing expertise with advanced scientific tools. Our approach enables the detection of nuanced responses in animal models, providing clear insight into the efficacy and safety of novel Crohn's disease therapies. With a commitment to high-quality data and analysis, we pave the way for confident decision making and put your program on the path to success.

Ileocolitis Research Services

With years of experience in the field of Crohn's disease, we have a professional R&D team and advanced experimental platforms to provide high-quality drug development solutions for ileocolitis. We can help clients develop various types of drugs for ileocolitis.

Crohn's Ileitis Research Services

We provide customized models of Crohn's ileitis, target discovery, and drug efficacy evaluation services to advance Crohn's ileitis research, including investigate the pathophysiology of Crohn's ileitis and develop novel therapies.

Gastroduodenal Crohn's Disease Research Services

Ace Therapeutics actively collaborates with researchers and pharmaceutical companies. Our extensive experience and reliable animal models allow us to provide a one-stop services for the preclinical development of your novel gastroduodenal Crohn's disease therapy.

Jejunoileitis Research Services

Ace Therapeutics provides preclinical jejunoileitis services using a variety of models and assays. With advanced technology and expertise, we advance the understanding of the complexities of jejunoileitis and the development of innovative therapies.

Chronic Granulomatous Disease Research Services

Thorough preclinical study is essential to assess the efficacy of your granulomatous colitis therapy. Through rigorous evaluation and validation, Ace Therapeutics provides reliable preclinical data to give your drug candidate the best chance of success.

Customized Preclinical Crohn's Disease Study Design for Your Therapy

As your dedicated preclinical partner, we work closely with you throughout the entire process of preclinical Crohn's disease study, providing expertise in study design, execution, analysis, and interpretation.

Specific Animal Models for CD

Chemically induced models: TNBS/DNBS, indomethacin
Spontaneous models: C3H/HejBir mice model, SAMP1/YitFc mice model
Genetically engineered models: NOD2 -/-, IL-10 -/- , IL-23 -/-, A20 -/-, NEMO -/-
Transgenic mouse models:STAT 4, HLA-B27
Mutation knock-in models: TNF^ΔARE
Adoptive transfer models: CD45RB^high transfer model

Comprehensive Preclinical Crohn's Disease Research

We provide important insight into the pathogenesis of human CD and test the efficacy of potential therapies to treat this devastating disease. Whether it is basic mechanistic or translational research, our leading scientists will assist in the design and execution of your study from inception to completion.

CD biomarker development
CD pathomechanism study
Discover new targets for CD
Drug efficacy evaluation
ADME/DMPK studies
Drug safety testing

At Ace Therapeutics, we are dedicated to advancing preclinical research in Crohn's disease. We help you develop effective therapies through animal models of Crohn's disease and assay platforms. Please do not hesitate to contact us.

Reference

Petagna, L., et al. (2020). Pathophysiology of Crohn's disease inflammation and recurrence. Biology direct, 15(1), 23.

! For research use only, not intended for any clinical use.