Ace Therapeutics is deeply engaged in the field of glaucoma research. We provide customized in vivo glaucoma models to comprehensively support researchers in enhancing basic glaucoma research and developing effective therapeutic strategies.
Animal Models of Glaucoma
As a group of eye disorders, glaucoma can be classified into primary glaucoma and secondary glaucoma. Primary glaucoma is further categorized into primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG), while secondary glaucoma encompasses various conditions that lead to increased intraocular pressure (IOP). The complexity of glaucoma makes it impossible for a single animal model to accurately mimic all aspects of human glaucoma. Therefore, multiple glaucoma models are typically required to gain a comprehensive understanding of various aspects of this disease.
Fig.1 Model systems and induction methods to create glaucoma animal models without chronic IOP elevation. (Tsai T, et al., 2024)
Glaucoma Animal Model Customization Services
Ace Therapeutics is dedicated to developing custom in vivo glaucoma models to meet the specific needs of our clients. Our animal model customization services encompass a range of model development approaches, including advanced gene editing techniques and controlled physicochemical methods.
- Genetic Models of Glaucoma
With our expertise in molecular biology and genetic tools, our team of experts is committed to developing genetic animal models that provide researchers with valuable insights into the mechanisms of glaucoma.
- Rodent Hypertensive Glaucoma Models
- DBA/2J mice
- Myocilin mutant mice
- Prss56 mutant mice
- Mouse Models of Normal Tension Glaucoma
- GLAST knockout mice
- EAAC1 knockout mice
- OPTN (E50K) transgenic mice
- Transgenic TBK1 mice
- Induced Models of Glaucoma
We utilize physical, chemical, and biological induction methods to develop a wild range of inducible glaucoma animal models. These models play a vital role in studying glaucoma pathogenesis and assessing the efficacy of pharmacological treatments.
- IOP-Dependent Animal Models of Glaucoma
- Intracameral injection model
- Hypertonic saline injection model
- Episcleral vein cauterization model
- Laser-induced model
- IOP-Independent Animal Models of Glaucoma
- Optic nerve crush/transection model
- Retinal ischemia-reperfusion injury model
- Excitotoxicity model
Tailored Glaucoma Models in Diverse Animal Species
Ace Therapeutics is working on developing glaucoma models in different animal species. Our animal model customization services allow you to select specific species to construct glaucoma models tailored to their experimental requirements.
- Rodents
- Rabbits
- Minipig
- Zebrafish
- Dogs
- Non-human primates
Ocular Drug Administration Routes
We have a team of professional ophthalmic technicians who can perform a variety of difficult routes of drug administration.
- Topical administration
- Intracameral injection
- Intravitreal injection
- Subretinal injection
- Subconjunctival injection
- Retrobulbar injection
Glaucoma Animal Model Assessment Services
We offer comprehensive evaluation services for glaucoma animal models.
- Measure the pressure inside animal models' eyes by tonometry.
- Evaluate retinal function in animals through electroretinogram (ERG).
- Measure the functional integrity of animal models' visual pathways through visual evoked potentials (VEP).
- Detect structural glaucomatous damage via optical coherence tomography (OCT).
- Detect glaucomatous optic neuropathy through color fundus photography (CFP).
- Assess visual abilities by optomotor response.
- Assess exploratory behavior and visual response by light/dark box (LDB) test.
- Assess visual and cognitive abilities by visual water task (VWT).
- Evaluate visual response by visual placing response test.
Ace Therapeutics provides comprehensive glaucoma animal model construction services, empowering our clients to advance their studies in glaucoma. Contact us to learn more about how our in vivo models can support your glaucoma program.
References
- Tsai T, et al. Glaucoma Animal Models beyond Chronic IOP Increase. Int J Mol Sci, 2024, 25(2): 906.
- Evangelho K, et al. Experimental Models of Glaucoma: A Powerful Translational Tool for the Future Development of New Therapies for Glaucoma in Humans-A Review of the Literature. Medicina, 2019, 55(6): 280.