Ace Therapeutics offers high-sugar diet-induced models of diabetes mellitus (DM) characterized by abnormal glucose and lipid metabolism, providing a basis for further research on the pathogenesis of DM and the development of antidiabetic drugs.

Overview of High-Sugar Diet-Induced Diabetic Models

It has been recently confirmed that the consumption of refined carbohydrates, especially high-fructose corn syrup (HFCS), in processed foods is associated with weight gain, high triglyceride levels, and insulin resistance in both human and animal models. To better understand the effects of refined carbohydrates on health and to develop therapies for diabetes, certain rodent models have proven instrumental. These models were obtained by feeding animals a high fructose or sucrose diet, which elevates triglyceride and glucose production in the liver, leading to insulin resistance and hypertriglyceridemia.

Fig. 1. A high-sugar diet induces more severe hyperglycemia than do other high-calorie diets. (Palanker Musselman L, et al., 2011)

Our High-Sugar Diet-Induced Diabetic Models

Our team specializes in constructing animal models of diabetes that closely mimic the human condition of metabolic syndrome using high-fructose diets. We offer customizable modeling services tailored to meet the specific needs of our clients.

Our In Vivo Analysis Services

Leveraging our extensive scientific expertise, we offer a one-stop service from study design to comprehensive data collection. Our validation of high-sugar diet-induced diabetic models primarily involves assessing metabolic, oxidative, and inflammatory parameters. With these verified and dependable animal models, we can comprehensively evaluate the effectiveness of your anti-diabetes drug candidates.

• Physiological parameter analysis
• Hormone analysis (C-peptide, proinsulin, and intact proinsulin)
• Plasma metabolic and oxidative parameter analysis (glycated serum protein, pyruvic acid, glucose, xanthine oxidase, lipid hydroperoxide, etc.)
• Plasma inflammatory parameter analysis (vascular endothelial growth factor (VEGF), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, etc.)
• Analysis of transcriptomic profiles in pancreatic and islet cells.

As a pioneer in the field of animal models and diabetes research services, Ace Therapeutics offers high-sugar diet-induced diabetic models tailored to meet the specific needs of researchers. Please feel free to contact us for more information on our custom animal models and dedicated support.

Reference

1. Palanker Musselman L, et al. (2011) A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Disease Models & Mechanisms. 4(6): 842-849.

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