High-fat diets not only promote obesity but also increase the risk of developing type 2 diabetes. Ace Therapeutics specializes in establishing animal models of diet-induced type 2 diabetes by chronic high-fat feeding. Our expertise enables us to offer high-quality diabetic models, aiding in the identification of therapeutic targets and the development of new drugs.

Overview of High-Fat Diet-Induced Diabetic Models

Type 2 diabetes mellitus (T2DM) is a type of non-insulin-dependent diabetes mellitus, accounting for more than 90% of diabetic patients. In recent years, the prevalence of T2DM has increased significantly, and it has become one of the major diseases that seriously threaten human health. High-fat diet and obesity are the main causative factors of T2DM. It is crucial to establish optimal animal models that closely mimic the pathogenesis and metabolic characteristics of human T2DM to explore the disease mechanisms and evaluate the efficacy of antidiabetic drugs. High-fat diet-induced diabetes models have become valuable tools for simulating the metabolic dysregulation associated with human T2DM.

Fig. 1. Schematic diagram of high-fat diet and the epigenetic process leading to diabetes. (Prasad M, et al., 2022)

Our High-Fat Diet-Induced Diabetic Models

At Ace Therapeutics, we specialize in customizing a variety of high-fat diet-induced diabetic animal models. Our team of expert scientists is dedicated to providing comprehensive support, including study design, model selection, and assistance with data analysis, ensuring the highest quality and relevance of research outcomes.

• Diabetes model induced by high-fat diet

We provide high-fat diet-induced models, which simulate the etiology of human T2DM with its unique advantages, especially the combination of obesity and diabetes pathogenesis. These models do not cause damage to vital organs, unlike chemically induced models, and are widely used in various etiological studies, particularly in investigating T2DM in the context of malnutrition and obesity.

• Diabetes model induced by high-fat diet and streptozotocin (STZ)

By feeding animals with a high-fat diet after low-dose STZ, we help clients establish useful T2DM models that would closely simulate the natural history and progress of disease events (from insulin resistance to β cell dysfunction) and metabolic characteristics of human T2DM. Compared with the simple high-fat diet-induced model, the high-fat diet + STZ-induced models have a shorter modeling period and higher modeling rate and are mostly used for the animal model of T2DM drug screening and evaluation.

For more information on how Ace Therapeutics' services can be tailored to meet your exact needs, please contact us. Our experience in drug development and expertise in diabetes can provide you with customized research solutions!

Reference

1. Prasad M, et al. (2022) A comprehensive review on high-fat diet-induced diabetes mellitus: an epigenetic view. The Journal of Nutritional Biochemistry. 107: 109037.

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