x
- Home
- About Diabetes
- Services
- Diabetes Mellitus Modeling Solutions
- R&D Services for Diabetes Mellitus and Diabetic Complications
- By Drug Development Process
- About Us
- Careers
- Contact Us
Cat. No.: DMM-001104
| Status | Age | Sex |
|---|---|---|
|
|
|
| Product Overview | |
|---|---|
| Model Description | Exon 3-7 of Cdk4 gene was deleted to generate Cdk4 knockout mice. |
| Strain Name | C57BL/6J-Cdk4em1 |
| Background Strain | C57BL/6J |
| SPF | Yes |
| Research Application | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase; which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). |
| Target Information | |
|---|---|
| Target Name | Cdk4 |
| Synonyms | Crk3 |
| Gene ID | 12567 |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
