Heart Failure Research and Drug Development Services

Heart failure is a clinical syndrome characterized by structural and functional changes due to a variety of causes, culminating in myocardial contractile dysfunction and decreased cardiac output. Ace Therapeutics provides integrated basic heart failure research and drug development services to help clients further explore the pathogenesis of heart failure and novel therapeutic approaches.

Pathogenesis of Heart Failure

Heart failure, a circulatory system syndrome caused by impairment of the heart's systolic or diastolic function, resulting in blood stagnation in the venous system and blood inadequate perfusion in the arterial system. Heart failure can be caused by almost all types of heart and macrovascular disease. The triggers for heart failure are usually due to an increased load on the heart, such as lung infections and overexertion.

• Abnormalities in Blood Supply
  When the heart is not functioning properly and compensating to a certain degree, there will be a decrease in cardiac output and stasis in the venous system.
• Neurohumoral Regulation
  When cardiac output is inadequate or ventricular end-diastolic pressure is elevated, the body compensates by initiating a series of neurohumoral mechanisms. However, this compensatory regulation leads to a further increase in cardiac load, which impairs cardiac function.
• Myocardial Hypertrophy/Myocardial Remodeling
  When primary myocardial injury results in a decrease in cardiac output, the myocardium compensates by hypertrophying. However, as the disease progresses, the diastolic function of the myocardium diminishes, leading to inadequate myocardial energy supply and ultimately irreversible myocardial damage.

Fig. 1 Quality of life with acute heart failure. (Arrigo M, et al., 2020)

Current Status of Drug Development for Heart Failure

The principle of drug therapy for heart failure is to relieve symptoms and improve prognosis, and the current therapeutic drugs include renin-angiotensin system inhibitors, receptor blockers, aldosterone receptor antagonists, and SGLT-2 inhibitors. In addition, some new drug therapies, such as oligonucleotide therapy, have been widely used in the research of drugs for heart failure.

Overview of Novel Drugs for Heart Failure

Ace Therapeutics is committed to supporting basic research and development of novel therapeutic approaches for heart failure by providing outsourced research services for disease model development and related research technology platforms.

Ace Therapeutics provides our customers with basic research, biomarker development, and novel therapy discovery services based on decades of experience in the field of heart failure. If you are interested in our research services for heart failure, please don't hesitate to contact us.

1. Arrigo, M.; et al. Acute heart failure. Nature Reviews Disease Primers. 2020, 6(1):16.