Coronary heart disease is the most common type of heart disease in clinical practice, with an extremely high prevalence worldwide, which has been the focus in the field of cardiovascular disease research for a long time. Ace Therapeutics aims to provide comprehensive services in coronary heart disease research to help clients explore the pathogenesis of coronary heart disease and accelerate new drug development.
It is believed that coronary heart disease, also known as coronary artery disease or ischemic heart disease, is caused by atherosclerosis of the coronary arteries, which results in narrowing or blockage of the blood vessel lumen, leading to a number of secondary symptoms such as myocardial ischemia and hypoxia.
Fig. 1 Schematic representation of
pathophysiological mechanisms. (Severino P, et al., 2020)
Current drug therapy strategies for coronary heart disease focus mainly on reducing heart load, dilating arteries, and unblocking blocked arteries. For the therapy of coronary heart disease, innovative drugs based on new targets and novel mechanisms are gradually becoming the trend.
| Drug Name | Drug Target | Original Organization | Drug Phase |
|---|---|---|---|
| Amlodipine Benzoate | VDCCs | Azurity Pharmaceuticals, Inc. | Approved |
| Evolocumab | PCSK9 | Amgen, Inc. | Approved |
| Inclisiran | PCSK9 | Alnylam Pharmaceuticals, Inc. | Approved |
| Cangrelor | P2Y12 Receptor | The Medicines Company (Spain) SL | Approved |
| Alferminogene tadenovec | FGF4 | Taxus Cardium Pharmaceuticals Group, Inc. | Phase 3 |
| Encoberminogene Rezmadenovec | VEGF-A/VEGFR | Cornell University | Phase 2 |
| MEDI-5884 | LIPG | AstraZeneca PLC | Phase 2 |
Ace Therapeutics is committed to supporting basic research and development of novel therapeutic approaches for coronary heart disease by providing outsourced research services for disease model development and related research technology platforms.
Research Models
Basic Research
Drug Development
For the research of coronary heart disease, the establishment of rational research models of coronary heart disease is a key link to further explore its pathogenesis, pathological process and novel therapeutic methods. We can provide different types of animal models or cell models for coronary heart disease research.
Custom Animal Model Development Services
Since atherosclerosis is the pathogenetic basis of various types of coronary heart disease, we are able to provide our clients with a variety of customized atherosclerosis and ischemia animal models to support their research on the pathogenesis of coronary heart disease and the development of novel therapeutic approaches.
Transgenic Animal Model Development Services
It is reported that the occurrence of coronary heart disease is associated with abnormal gene expression. We can provide customized services for developing transgenic or knockout animal models, including but not limited to the following genes:
Genetically Engineered Mouse Models
We can provide the following high quality genetically engineered mice for coronary heart disease research.
Cardiomyocytes
For in vitro studies, we can provide our clients with the following cardiomyocyte cell lines as well as human induced pluripotent stem cell constructs.
For coronary heart disease research, we have a series of well-established research technology platforms to help our clients investigate the pathogenesis of coronary heart disease and evaluate the efficacy of drugs or biologics.
Pathogenesis Research Services
Genetic factors have been reported to play a crucial role in the development of coronary heart disease. We have a complete multi-omics research technology platform, which can help our clients to explore the disease development mechanism of coronary heart disease at gene level, protein expression level, and metabolite analysis.
Pathology and Imaging Services
For animal models of coronary artery disease, pathology and imaging tests can most intuitively reflect the status of the animal model, thus enabling intuitive model validation and efficacy assessment. We can provide pathology and imaging services for animal experiments, including but not limited to:
Based on our specialized novel drug research technology platform, we can provide our clients with research outsourcing services for drug development for coronary heart disease, including but not limited to the following drug types and targets:
R&D Services by Drug Type
R&D Services by Target
Ace Therapeutics has been deeply involved in cardiovascular disease research for many years, and has accumulated rich knowledge of coronary heart disease research. We can provide our clients with coronary heart disease research model construction, basic research, and novel therapy discovery services. If you are interested in our research services for coronary heart diseases, please don't hesitate to contact us.
Ace Therapeutics offers comprehensive solutions and R&D services to researchers worldwide to advance the field of cardiovascular diseases.
We do not provide medical care for patients.
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