Angina Pectoris Research and Drug Development Services

Angina pectoris, the chest pain that is caused by myocardial ischemia, is generally caused by a blockage or spasm of the coronary arteries. Ace Therapeutics aims to provide research outsourcing services, including animal models, diagnostic technology platforms, and drug discovery research services, to advance basic research and drug development in angina pectoris.

Pathogenesis of Angina Pectoris

When the cardiac load is increased, the oxygen consumption required for the heart is also increased at the same time, but the coronary blood flow cannot meet the demand accordingly, thus leading to acute transient ischemia and hypoxia of the myocardium, which will cause angina pectoris. When the myocardium is under the condition of hypoxia, acidic metabolites such as lactic acid and pyruvic acid stimulate the cardiac afferent nerves and cause nociception, but the nociceptive site is most often not in the cardiac area but in the posterior part of the sternum.

• Stable Angina pectoris
  Stable angina is mostly caused by myocardial ischemia due to overexertion, and its onset is relatively short and mild, with a relatively regular frequency. At the onset of the disease, oral nitroglycerin can be used to alleviate symptoms.
• Unstable Angina pectoris
  The onset of unstable angina is irregular, and the pain level is unstable. Additionally, unstable angina may progressively worsen leading to myocardial infarction or even sudden death.

Fig. 1 Schematic presentation of mechanisms for cardiac chest pain. (Jain A, et al., 2017)

Current Status of Drug Development for Angina Pectoris

Relief of angina attack symptoms and prevention of myocardial ischemic events are the main goals in the development of drug therapies for angina pectoris. While traditional drug targets and therapeutic strategies include vasodilatation, cardiac load reduction, and cholesterol lowering, in recent years a number of emerging drug types and new targets have also been heavily utilized in the development of drugs for the therapy of angina pectoris.

Overview of Novel Drugs for Angina Pectoris

By providing outsourced research services for disease model development and related research technology platforms, Ace Therapeutics supports basic research and the development of novel therapeutic approaches for angina pectoris.

Ace Therapeutics has been involved in cardiovascular disease research for many years and has accumulated extensive experience in angina pectoris research. We aim to provide angina-based basic research, biomarker development, and novel therapies discovery services for our clients. If you are interested in the services for angina pectoris research, please don't hesitate to contact us.

1. Jain, A.; et al. Advancements in pharmacotherapy for angina. Expert opinion on pharmacotherapy. 2017, 18(5): 457-469.