Preclinical Cryptogenic Stroke Research Services
The majority of ischemic strokes arise from well-defined etiologies, including large vessel atherothromboembolism, small vessel occlusive disease, cardioembolism, or other unusual mechanisms. However, a significant number of ischemic strokes occur without a identified cause, and these are classified as cryptogenic strokes. Despite significant advancements in our understanding of ischemic strokes, cryptogenic strokes continue to present considerable challenges in both their diagnosis and treatment. Investigating the underlying mechanisms of these strokes is crucial for selecting appropriate therapies aimed at reducing the risk of recurrence.
Fig. 1 Heterogenity of cryptogenic stroke and TIA etiologies in the Nordic Atrial Fibrillation and Stroke (NOR-FIB) study. (Ratajczak-Tretel, et al., 2023)
With extensive experience in preclinical cryptogenic stroke studies, Ace Therapeutics is your reliable partner in advancing preclinical research. Our cutting-edge facilities, combined with customized animal models and a wide range of behavioral assays, empower you to gain a comprehensive understanding of the pathogenesis of cryptogenic stroke and discover potential breakthroughs.
Mechanisms of Cryptogenic Stroke Research Services
The etiology of cryptogenic stroke remains elusive due to the transient or reversible nature of the event. We provide reliable services to help our clients investigate various pathogenic mechanisms associated with cryptogenic stroke, such as cardiac abnormalities of uncertain risk, arteriogenic embolism, paradoxical embolism, and unknown prothrombotic disorders.
Diagnostic Development for Cryptogenic Stroke
We assist clients in developing a variety of diagnostic tools and materials specifically designed for diagnosing cryptogenic stroke.
- We help clients develop advanced probes and materials for brain imaging in cryptogenic stroke utilizing MRI and CT technologies.
- We help clients develop probes and materials for both intracranial and extracranial angiography in cryptogenic stroke. Our methodologies incorporate CT angiography (CTA), carotid duplex ultrasound, and transcranial Doppler imaging.
- We offer a range of services that includes rapid plasmin reagin (RPR) testing, erythrocyte sedimentation rate (ESR), hypercoagulable testing, and genetic analysis. These assessments are designed to assist our clients in identifying important biomarkers present in blood and cerebrospinal fluid, such as brain natriuretic peptide (BNP), N-terminal pro-BNP (NT-proBNP), and D-dimer.
Preclinical Evaluation of Cryptogenic Stroke Therapies
We are dedicated to assisting our clients in the development of a wide range of drugs for cryptogenic stroke, including antiplatelet agents and anticoagulants.
Preclinical Imaging Services for Cryptogenic Stroke Therapy Development
| Neuroimaging service | Provide certain lesion patterns on diffusion-weighted MRI to help clients identify the cryptogenic stroke mechanism. |
| Vascular imaging service |
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Cardiac Testing Services for Cryptogenic Stroke Therapy Development
| Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) | TTE and TEE can be performed on animal models of cryptogenic stroke to help our clients study the mechanism of the cryptogenic stroke and develop stroke treatment strategies. |
| Monitoring cardiac and other indicators of occult atrial fibrillation | Detect atrial fibrillation (AF) in animal models of cryptogenic stroke by analyzing serum levels of troponin and pro-BNP. |
Ace Therapeutics specializes in providing comprehensive preclinical contract services for researchers and pharmaceutical companies focused on cryptogenic stroke. With our extensive experience and expertise in disease modeling, we offer customized solutions for the preclinical development of your innovative therapies targeting this complex condition. If you are interested in our services, please contact us for more information.
- Zhang, C., & Kasner, S. (2016). Diagnosis, prognosis, and management of cryptogenic stroke. F1000Research, 5.
- Ratajczak-Tretel, B., et al. (2023). Underlying causes of cryptogenic stroke and TIA in The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study–the importance of comprehensive clinical evaluation. BMC neurology, 23(1), 115.
