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- BBB DamageCell Death and ApoptosisNeuroinflammationNeuronal Damage and RepairOxidative StressVascular Mechanisms
- 3D BBB Models
- Organ-on-a-Chip BBB ModelsTranswell Models3D BBB Models Culture Substrate
- 3D HydrogelsCollagensAnmial BBB ModelsCell Lines for BBB Modeling
- Immortalized CellsPrimary CellsStem Cells
Collagens
Collagen is the main component of connective tissue and is abundant in mammals. It is the most widely used extracellular matrix in 3D cell culture to promote cell attachment, growth, differentiation, migration and tissue morphogenesis.
In the 3D BBB model, collagen is used as the main component of the cell culture matrix to provide a support and attachment matrix for cells, thus supporting the simulation study of complex cell interactions and biological processes.
The 3D BBB model is a three-dimensional cell culture model that simulates the blood-brain barrier and is used to study related neurobiology and drug delivery issues. In order to reproduce real physiological conditions, the 3D BBB model uses a collagen matrix to culture brain vascular endothelial cells and other related cells to form a microenvironment with blood-brain barrier function. Collagen plays different roles when creating a three-dimensional blood-brain barrier (BBB) model culture matrix.
- Has good biocompatibility and can promote cell attachment and growth.
- Has a three-dimensional structure and can simulate the characteristics of real tissues.
- Helps form the structure and function of brain vascular endothelial cells and related cells.
It is worth noting that the choice of collagen for the 3D BBB model culture matrix should be based on the specific requirements of the study and the desired matrix functionality. Furthermore, combining different types of collagen or using mixtures of collagen with other ECM components can further enhance the biomimetic properties and functionality of BBB model culture substrates.
Ace Therapeutics produces and supplies different types of collagen to help you construct an ideal, stable 3D BBB model in vitro that meets your research needs.
Cat.# Name Description Price BBM-3C-061 Collagens Type I-C Collagens Type I-P is pepsin-solubilized Type-I collagen derived from pig skin. This product is suitable for coating.inquiry BBM-3C-062 Collagens Type Ⅳ Collagens Type IV is derived from bovine tissue treated with pepsin. This product does not gel and needs to be mixed with collagen type I-A.inquiry BBM-3C-063 Collagen Gel Culturing Kit Collagen Gel Culturing Kit from Ace Therapeutics is a ready-to-use kit for form gel. This kit consists of the all reagents required for the experiment, including cellmatrix type I-A, Ham F-12 culture medium, MEM Hanks culture medium, and reconstitution buffer.inquiry BBM-3C-064 Collagen, Type I, from Rat Tail The rat tail collagen I provided by Ace Therapeutics is prepared according to the Birkedal-Hansen method through acetic acid extraction, sodium chloride precipitation, and disodium hydrogen phosphate precipitation. This product is derived from a rat tail, dissolved in 0.02M HAc solution, and the purity is greater than 90% as determined by SDS-PAGE, and it is sterile.inquiry BBM-3C-065 Collagen, Type I, from Mouse Tail The mouse tail collagen I provided by Ace Therapeutics is prepared according to the Birkedal-Hansen method through acetic acid extraction, sodium chloride precipitation, and disodium hydrogen phosphate precipitation. This product is derived from a mouse tail, dissolved in 0.02M HAc solution, and the purity is greater than 90% as determined by SDS-PAGE, and it is sterile.inquiry BBM-3C-066 Collagen Type I, from Rat Tail The rat tail collagen I provided by Ace Therapeutics is prepared according to the Birkedal-Hansen method through acetic acid extraction, sodium chloride precipitation, and disodium hydrogen phosphate precipitation. This product is a sterile solution dissolved in 6mM HAc, with a concentration of 5mg/ml. Each batch of products passes cell culture testing (including three-dimensional space culture) to ensure quality reliability. Note: Please keep the entire operation at a low temperature on ice because rat tail collagen I at room temperature can quickly form a gel.inquiry BBM-3C-067 Cultrex 3-D Culture Matrix Rat Collagen I Cultrex 3-D Culture Matrix Collagen I from Ace Therapeutics is purified from rat tail tendon with high concentrations. This product is capable of polymerizing to form hydrogels and is a purified matrix ECM protein specifically designed and developed for 3D culture.inquiry BBM-3C-068 Cultrex Mouse Collagen IV Cultrex Mouse Collagen IV from Ace Therapeutics is a stromal extracellular matrix protein purified from a murine engelbreth-holm-swarm (EHS) tumor. This product can promote cell adhesion in cell and tissue cultures as well as be used as a hydrogel or thin coating for tissue culture vessels.inquiry BBM-3C-069 Cultrex Rat Collagen I Cultrex Rat Collagen I from Ace Therapeutics is a high concentration matrix extracellular matrix protein purified from rat tail tendon. This product is capable of polymerizing to form hydrogels and is a purified matrix ECM protein specifically designed and developed for 3D culture.inquiry BBM-3C-070 Cultrex Bovine Collagen I Cultrex Bovine Collagen I from Ace Therapeutics is a purified stromal extracellular matrix protein from fetal bovine extensor tendons and is pepsin-treated to remove telopeptides. This product promotes cell adhesion for cell and tissue culture.inquiry BBM-3C-071 Cultrex Rat Collagen I, Lower Viscosity Cultrex Rat Collagen I, Low Viscosity from Ace Therapeutics is a purified stromal extracellular matrix protein from rat tail tendons. This product is provided at a standard concentration that is lower in viscosity, making it easier to work with.inquiry All of our products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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