Blood Glutamate Scavenger Development for Stroke

Glutamate is involved in the pathological process of excitotoxicity, and after stroke, excess glutamate in the cerebrospinal fluid damages and kills neuronal cells. In response to the failure of strategies to interfere with glutamate activity, another approach has been proposed to neutralize the deleterious effects of glutamate by eliminating excess glutamate from the brain by lowering blood glutamate levels, thereby accelerating the outflow of glutamate from the brain into the blood. Animal studies have shown that glutamate scavengers are effective in reducing blood glutamate concentrations and improving neurological outcomes after traumatic brain injury and stroke in rats.

Fig. 1. Basic mechanism of glutamate scavenging. (Kaplan-Arabaci et al., 2022)

Our Blood Glutamate Scavenger Development Services

At Ace Therapeutics, we are committed to advancing the treatment of stroke by developing novel drugs that counteract glutamate excitotoxicity. Our blood glutamate scavenger development service is designed to help clients develop effective and safe stroke drugs to reduce blood glutamate levels, thereby mitigating its damaging effects on brain cells and promoting neuroprotection in ischemic stroke. Our comprehensive services include synthesis, optimization and preclinical evaluation of blood glutamate scavengers. We can provide expert guidance to our clients and ensure that each study is supported by our trademark quality and diligence.

What Blood Glutamate Scavengers Can We Develop?

Design and Synthesis of Blood Glutamate Scavengers

Our experienced team utilizes advanced technologies to design and synthesize novel compounds with high affinity and selectivity for glutamate. We employ structure-based drug design strategies, molecular modeling, and computational simulations to identify potential lead compounds with optimal drug-like properties. Through iterative medicinal chemistry optimization, we strive to improve the efficacy, safety, and pharmacokinetic properties of blood glutamate scavengers.

In Vivo Evaluation of Blood Glutamate Scavengers

We provide animal models of ischemic stroke to evaluate the efficacy and safety of blood glutamate scavengers.

• Fluorescence method to measure cerebrospinal fluid glutamate concentration
• Fluorometric measurement of blood glutamate
• MRI measurement of infarct volume
• Measurement of cerebral edema
• Behavioral assessments: sucrose preference test, elevated cross maze task, dominant-submissive behavior
• Measurement of blood-brain barrier permeability

Pharmacokinetic and Toxicity Analysis of Blood Glutamate Scavengers

We conduct comprehensive studies to evaluate the absorption, distribution, metabolism, and excretion characteristics of blood glutamate scavengers. In addition, we conduct extensive toxicity analyses to assess the safety of blood glutamate scavengers. Our approach is designed to reduce risk, minimize time delays and reduce costs associated with the advancement of blood glutamate scavengers.

Through our comprehensive blood glutamate scavenger synthesis, optimization and preclinical evaluation services, Ace Therapeutics is committed to helping clients develop novel and effective blood glutamate scavengers to advance stroke therapy. If you are interested in our services, please do not hesitate to contact us!

1. Kaplan-Arabaci, O., et al. (2022). Glutamate scavenging as a neuroreparative strategy in ischemic stroke. Frontiers in Pharmacology, 13, 866738.