Products
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- BBB DamageCategories
- Neurotransmitter Antibodies & Receptor Antibodies
- Ionotropic Receptor AntibodiesMetabotropic Receptor AntibodiesNeurotransmitter AntibodiesTransporter AntibodiesSignal Channel Antibodies
- Calcium Channel AntibodiesChloride Channel AntibodiesDense-Core Vesicles AntibodiesNitric Oxide Channel AntibodiesStroke Pathology Antibodies
- Neurogenesis AntibodiesNeuronal Growth & Development AntibodiesNeuronal Growth & Development AntibodiesNeuronal Metabolism AntibodiesSignal Transduction AntibodiesStroke-Related Cell Markers Antibodies
- Glial Cell Marker AntibodiesNeural Stem Cell Marker AntibodiesNeuron Marker AntibodiesSynaptic Marker AntibodiesCell Death and ApoptosisNeuroinflammationNeuronal Damage and RepairOxidative StressVascular Mechanisms
- 3D BBB Models
- Organ-on-a-Chip BBB ModelsTranswell Models3D BBB Models Culture Substrate
- 3D HydrogelsCollagensAnmial BBB ModelsCell Lines for BBB Modeling
- Immortalized CellsPrimary CellsStem Cells
3D BBB Models Culture Substrate
The BBB is a specialized barrier in the brain that regulates the entry of molecules and cells from the bloodstream into the brain. It plays a crucial role in protecting the brain from harmful substances and maintaining its homeostasis.
Traditional 2D cell model of BBB culture is performed on simple, nonporous two-dimensional (2D) surfaces. Despite the method being easy and convenient, can result in certain well-documented artifacts. The 3D BBB model culture substrate refers to the three-dimensional culture system used for culturing and studying the blood-brain barrier (BBB) model in vitro, which aims to mimic the physiological conditions of the brain's microenvironment, allowing researchers to study BBB function and dysfunction in a controlled laboratory setting. It typically consists of a specialized culture substrate that supports the growth and differentiation of brain endothelial cells, which form the main component of the BBB. The substrate is often coated with extracellular matrix proteins like collagen or laminin to provide a suitable surface for cell attachment and growth.
A well-established method for culturing 3D BBB models is to culture cells on structural scaffolds, which are typically composed of biopolymers, such as 3D hydrogels and collagens, arranged to mimic the physiological extracellular matrix (ECM).
Highlighted below are the types of brackets Ace Therapeutics offers for 3D BBB model culture.
Click on the Links to Access Our 3D BBB Model Culture Substrate:
Cat.# Name Description Price BBM-3C-026 Goat Collagen Type I, 10 mg Goat Collagen Type I, 10 mg from Ace Therapeutics is purified from goat tissue. Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.inquiry BBM-3C-027 Mouse Collagen Type I, 1 mg Mouse Collagen Type I, 1 mg from Ace Therapeutics is purified from mouse tail tendon. Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.inquiry BBM-3C-028 Porcine Collagen Type I, 30 mg Porcine Collagen Type I, 30 mg from Ace Therapeutics is purified from porcine tendon. Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.inquiry BBM-3C-029 Bovine Collagen Type III, 10 mg Bovine Collagen Type III, 10 mg from Ace Therapeutics is purified from bovine (calf ) skin. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function.inquiry BBM-3C-030 Bovine Collagen Type V (Atelocollagen), 1 mg Bovine Collagen Type V (Atelocollagen), 1 mg from Ace Therapeutics is purified from bovine placenta.inquiry BBM-3C-031 Human Collagen Type I, 0.1 mg Human Collagen Type I, 0.1 mg from Ace Therapeutics is purified from human placenta. Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.inquiry BBM-3C-032 Human Collagen Type II, 0.1 mg Human Collagen Type II, 0.1 mg from Ace Therapeutics is purified from human cartilage.inquiry BBM-3C-033 Human Collagen Type III, 0.1 mg Human Collagen Type III, 0.1 mg from Ace Therapeutics is purified from human cartilage. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function. Type III collagen together with type I collagen are the main constituents of the interstitial matrix.inquiry BBM-3C-034 Human Collagen Type IV, 0.1mg Human Collagen Type IV, 0.1mg from Ace Therapeutics is purified from human cartilage.inquiry BBM-3C-035 Human Collagen Type V, 0.1mg Human Collagen Type V, 0.1mg from Ace Therapeutics is purified from human placenta. Type V collagen, a fibrillar collagen, is critical for the fibrillation of types I and III collagen, contributing to optimal fibril formation and tissue quality.inquiry BBM-3C-036 Rat Tail Tendon Collagen Type I Rat Tail Tendon Collagen Type I from Ace Therapeutics is purified from rat tail by the Birkedal-Hansen method. This product can form a three-dimensional glue with a certain strength when the concentration is above 1mg/mL and the pH is around 7. Note: This product can quickly gel at RT when the pH is neutral. Keep the temperature as low as possible during the operation.inquiry BBM-3C-037 Soluble Collagen Type I Soluble Collagen TypeⅠ from Ace Therapeutics is purified fromBovine achilles tendon by the Birkedal-Hansen method.inquiry BBM-3C-038 Rat Tail Collagen Type I Rat Tail Tendon Collagen Type I from Ace Therapeutics is purified from rat tail by the Birkedal-Hansen method. This product can form a three-dimensional glue with a certain strength when the concentration is above 1mg/mL and the pH is around 7.inquiry BBM-3C-039 Rat Tail Collagen Type I (from Rat Tail Tendon) Rat Tail Collagen Type I (from Rat Tail Tendon) from Ace Therapeutics is purified from rat tail by the Birkedal-Hansen method. This product has the advantages of high purity (SDS-PAGE>85%), low endotoxin, and easy storage and transportation, making it convenient for customers to prepare the required concentration.inquiry BBM-3C-040 Collagen Type IV from Human Cell Culture Collagen Type IV from Human Cell Culture from Ace Therapeutics is derived from human fibroblasts and epithelial cells in a co-culture system, which creates an in vitro ECM (extracellular matrix) and serves as an excellent biological scaffold for three-dimensional cell culture.inquiry All of our products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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