Products
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- BBB DamageCategories
- Neurotransmitter Antibodies & Receptor Antibodies
- Ionotropic Receptor AntibodiesMetabotropic Receptor AntibodiesNeurotransmitter AntibodiesTransporter AntibodiesSignal Channel Antibodies
- Calcium Channel AntibodiesChloride Channel AntibodiesDense-Core Vesicles AntibodiesNitric Oxide Channel AntibodiesStroke Pathology Antibodies
- Neurogenesis AntibodiesNeuronal Growth & Development AntibodiesNeuronal Growth & Development AntibodiesNeuronal Metabolism AntibodiesSignal Transduction AntibodiesStroke-Related Cell Markers Antibodies
- Glial Cell Marker AntibodiesNeural Stem Cell Marker AntibodiesNeuron Marker AntibodiesSynaptic Marker AntibodiesCell Death and ApoptosisNeuroinflammationNeuronal Damage and RepairOxidative StressVascular Mechanisms
- 3D BBB Models
- Organ-on-a-Chip BBB ModelsTranswell Models3D BBB Models Culture Substrate
- 3D HydrogelsCollagensAnmial BBB ModelsCell Lines for BBB Modeling
- Immortalized CellsPrimary CellsStem Cells
3D BBB Models Culture Substrate
The BBB is a specialized barrier in the brain that regulates the entry of molecules and cells from the bloodstream into the brain. It plays a crucial role in protecting the brain from harmful substances and maintaining its homeostasis.
Traditional 2D cell model of BBB culture is performed on simple, nonporous two-dimensional (2D) surfaces. Despite the method being easy and convenient, can result in certain well-documented artifacts. The 3D BBB model culture substrate refers to the three-dimensional culture system used for culturing and studying the blood-brain barrier (BBB) model in vitro, which aims to mimic the physiological conditions of the brain's microenvironment, allowing researchers to study BBB function and dysfunction in a controlled laboratory setting. It typically consists of a specialized culture substrate that supports the growth and differentiation of brain endothelial cells, which form the main component of the BBB. The substrate is often coated with extracellular matrix proteins like collagen or laminin to provide a suitable surface for cell attachment and growth.
A well-established method for culturing 3D BBB models is to culture cells on structural scaffolds, which are typically composed of biopolymers, such as 3D hydrogels and collagens, arranged to mimic the physiological extracellular matrix (ECM).
Highlighted below are the types of brackets Ace Therapeutics offers for 3D BBB model culture.
Click on the Links to Access Our 3D BBB Model Culture Substrate:
Cat.# Name Description Price BBM-3C-117 3D Organoid Hydrogel 3D Organoid Hydrogel is a ready-to-use hydrogel system for the three-dimensional (3D) rganoid culture. The product without xeno-free (no animal origin) supports the growth of patient-derived organoids or organoids developed from pluripotent stem cells (PSC), co-culture, and PDX models.inquiry BBM-3C-118 3D Stem Hydrogel 3D Stem Hydrogel is a ready-to-use hydrogel system for the three-dimensional (3D) mesenchymal stem cells culture. It is animal-free and can be used directly with cells for 3D culture or to generate hydrogel cell beads.inquiry BBM-3C-119 3D MSC Hydrogel Kit 3D MSC Hydrogel Kit is a ready-to-use hydrogel system for the three-dimensional (3D) mesenchymal stem cells (MSC) culture. It is animal-free and can be used directly with cells for 3D culture or to generate hydrogel cell beads.inquiry BBM-3C-120 3D Hydrogel Kit (Native) 3D Hydrogel Kit (Native), a natural, animal-free, ready-to-use hydrogel, creates a 3D cell culture environment that mimics the extracellular matrix (ECM) to support cell growth and differentiation.inquiry BBM-3C-121 3D Cell Culture Hydrogel (PNIPAAm-PEG) 3D Cell Culture Hydrogel (PNIPAAm-PEG) from Ace Therapeutics is a highly lipophilic, temperature-reversible polymer gel. This product transforms into a gel at higher temperatures (37°C) while remaining liquid at lower temperatures (4°C). This product is used for 3D cell culture, tissue engineering, and drug delivery.inquiry BBM-3C-016 Bovine Collagen Type VI, Lyophilized, 0.1mg Bovine Collagen Type VI, Lyophilized, 0.1mg from Ace Therapeutics is purified from the bovine placenta. The product is the major collagenous component of microfibrils in elastic fibers and in a larger variety of tissues, which consist of two α-chains of ca.inquiry BBM-3C-017 Bovine Collagen Type I (Atelocollagen) , 30 mg Bovine Collagen Type I (Atelocollagen) from Ace Therapeutics is purified from bovine tendons. Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.inquiry BBM-3C-018 Mouse Collagen Type I (Atelocollagen), 1 mg Mouse Collagen Type I (Atelocollagen) from Ace Therapeutics is purified from the mouse tail tendon. Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.inquiry BBM-3C-019 Rat Collagen Type I (Atelocollagen), 30 mg Rat Collagen Type I (Atelocollagen) from Ace Therapeutics is purified from the rat tail tendon. Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.inquiry BBM-3C-020 Bovine Collagen Type I and III, 10 mg Bovine Collagen Type I and III, 10 mg from Ace Therapeutics is purified from calf skin. Type I collagen is the most abundant collagen and is found in connective tissues including tendons, ligaments, dermis, and blood vessels. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function.inquiry BBM-3C-021 Canine Collagen Type I and III, 10 mg Canine Collagen Type I and III, 10 mg from Ace Therapeutics is purified from canine collagen. Type I collagen is the most abundant collagen and is found in connective tissues including tendons, ligaments, dermis, and blood vessels. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function.inquiry BBM-3C-022 Mouse Collagen Type I and III, 5 mg Mouse Collagen Type I and III, 5 mg from Ace Therapeutics is purified from rom tail tendons of the mouse. Type I collagen is the most abundant collagen and is found in connective tissues including tendons, ligaments, dermis, and blood vessels. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function.inquiry BBM-3C-023 Porcine Collagen Type I and III, 10 mg Porcine Collagen Type I and III, 10 mg from Ace Therapeutics is purified from pig’s tissue. Type I collagen is the most abundant collagen and is found in connective tissues including tendons, ligaments, dermis, and blood vessels. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function.inquiry BBM-3C-024 Rat Collagen Type I and III, 10 mg Rat Collagen Type I and III, 10 mg from Ace Therapeutics is purified from rat tissue. Type I collagen is the most abundant collagen and is found in connective tissues including tendons, ligaments, dermis, and blood vessels. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function.inquiry BBM-3C-025 Bovine Collagen Type I, 10 mg Bovine Collagen Type I, 10 mg from Ace Therapeutics is purified from bovine skin. Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.inquiry All of our products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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