Ace Therapeutics offers you a full range of biomarker services for your anti-psychotic drug development needs. You don't even have to think about all the quality control, lengthy development steps, and data analysis. We can perform your experiments from a variety of biological samples: tissues, cell lines, and RNA. we will handle your samples from the beginning to the final quality control and data analysis in a very short time on our high throughput molecular platform.

Introduction of Psychiatric Biomarker Testing

For many years, researchers have been trying to identify diagnostic and prognostic biomarkers for psychiatric disorders, including schizophrenia, major (monophasic) depression and bipolar disorder. Identifying such biomarkers will help in the diagnosis of these disorders, as well as in the possible development of effective psychiatric drugs to treat them.

Fig. 1 Current and emerging treatment response biomarkers in anxiety disorders. (Strawn JR, et al., 2020)

Biomarker Testing Services

We provide end-to-end biomarker analysis during antipsychotic drug discovery and preclinical studies. Our scientists have extensive experience in establishing biomarker assays to quantify proteins, peptides and small molecules in various biological matrices such as blood, plasma, serum, urine, cerebrospinal fluid, organ tissue homogenates, etc. You can take advantage of our biomarker testing services for over 1,000 analytes on MSD, Luminex, ELISA, LC-MS/MS, qPCR and Western Blot.

• Predictive Biomarker Identification Services in Psychiatry

Our scientific experts and biomarker lab staff can help you develop a translational design strategy to identify, develop predictions for multiple biomarkers in parallel, so the most relevant biomarkers can be identified faster and give you early proof-of-concept.

• Biomarker Analysis Services in Psychiatry

We have extensive experience in the analysis of biomarkers of stress and other psychiatric disorders in a wide range of biological matrices. With years of experience in assay design and sample processing, we can provide high-quality biomarker analysis services to support your anti-psychotic drug discovery pipeline.

• Biomarker Validation Services in Psychiatry

We are dedicated to providing biomarker validation services to test the sensitivity, specificity, and analytical validity of our clients' biomarker candidates. We use systems biology and integrated platform approaches for biomarker validation, thus providing the best opportunity for the early identification of the most promising biomarker candidates.

Our Biomarker Analysis Platform

• Genomics and transcriptomics
• Mass Spectrometry-based discovery proteomics
• Immunoassays (ELISA, MSD, Luminex)
• Flow cytometry
• Histological and digital pathology assays, in-situ hybridization/RNAScope
• Immune profiling: Cytokine and chemokine profiling; FACS, RNA-Seq, Mouse I/O RNA-Seq

Applications of Biomarker Testing

• Antipsychotic drug evaluation and development
• Cytokine, inflammatory factor, chemokine, enzyme concentration assays
• Quantitative analysis of phosphorylated proteins and apoptosis-related proteins in cell signaling
• Autoimmune function analysis
• HLA typing assay
• Psychiatric disease pathology research
• Signaling pathway research
• Gene mutation research

Why Choose Us?

• Preclinical biomarker lab testing services for over 1,000 analytes
• Accelerated biomarker assay development for ELISA, Luminex, MSD, LC-MS/MS, qPCR, Western Blot, etc.
• GLP biomarker assay validation and bioanalysis

Ace Therapeutics can utilize off-the-shelf assays, transfer and validate externally developed assays to our laboratory, or develop custom assays from scratch to meet unique analytical requirements. If you are interested in our biomarker assay services, please feel free to make an inquiry.

Reference

1. Strawn JR, Levine A. Treatment Response Biomarkers in Anxiety Disorders: From Neuroimaging to Neuronally-Derived Extracellular Vesicles and Beyond. Biomark Neuropsychiatry. 2020, 3:100024.