ADME Profiling Services of Antipsychotics

ADME Profiling Services of Antipsychotics

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ADME (Absorption, Distribution, Metabolism, and Excretion) analysis of antipsychotic drugs is a crucial step in the drug development process, enabling the evaluation of pivotal processes influencing the in vivo behavior of drug candidate compounds. Ace Therapeutics offers comprehensive ADME profiling services for antipsychotics, including high-throughput ADME screening, in vitro drug metabolism assays, and drug permeability and transport assays. We are dedicated to providing our clients with reliable ADME analysis data, which will assist you in making well-informed decisions throughout the antipsychotic drug development process.

Importance of ADME Profiling

A successful antipsychotic drug should enter the body in an appropriate manner, be reasonably well distributed to tissues and organs, be metabolized in a manner that does not result in immediate loss of activity, be eliminated in an appropriate manner, and be assured of the absence of toxicity. These processes are closely interrelated and cover the entire in vivo process from administration to elimination. ADME analyzes the absorption, distribution, metabolism, and excretion characteristics of a drug candidate compound. The determination of ADME properties for a drug candidate can effectively predict the bioavailability and bioactivity of the drug, providing an important reference value for the development of antipsychotics.

Our ADME Profiling Services for Antipsychotics

Ace Therapeutics is aware of the varying requirements for ADME assays at different stages of drug development. Our experienced experts will provide custom ADME analysis services based on client needs and drug properties. Our advanced in vitro ADME platform, LC-MS/MS bioanalytical and metabolite characterization technologies, will support your antipsychotic drug development with the following services:

High throughput ADME screening
  • Water solubility (thermodynamics & kinetics)
  • Metabolic stability (microsomal stability, plasma stability, hepatocyte stability, etc.)
  • Permeability
  • Protein binding (plasma, microsomes, brain tissue)
  • CYP inhibition
  • CYP analysis
In vitro drug metabolism assays
  • Hepatocyte stability assay
  • S9 stability assay
  • Microsomal stability testing
  • Plasma stability testing
  • Metabolite identification
  • Metabolic pathway identification
  • CYP/UGT response test
  • CYP induction test
  • CYP inhibition assay (single point inhibition, time-dependent inhibition)
  • UGT inhibition assay (and other non-CYP metabolizing enzymes)
Drug permeability and transport assays
  • Caco-2 permeability transport assay (unidirectional or bidirectional)
  • MDCK/MDR1-MDCK permeability assay
  • Permeability of artificial membranes assay (PAMPA)
  • Transporter assay (P-gp, BCRP, BSEP, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, OCT2, etc. optional)

Advantages of Ace Therapeutics

  • Specialized ADME laboratory and experienced research team.
  • Highly sensitive detection technologies such as LC-MS/MS and AMS.
  • High-quality experimental data and comprehensive data analysis.

Ace Therapeutics offers advanced analytical technologies and extensive experience to help you save time, reduce costs, and conserve resources in your antipsychotic drug development efforts. Our high-quality ADME data support will provide critical information that is essential for the development of antipsychotic drugs. Please contact us for more details and we will be happy to assist you.


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