Ace Therapeutics is committed to providing comprehensive functional genomics research services to help clients delve into the genetics of psychiatric disorders. Our experienced research team will provide customized research protocols based on the client's specific disease area of interest. We will examine which genetic variants have biological effects, how they affect the activity of the genes involved, and how these changes reshape brain function. The results will provide a solid scientific basis for the accurate diagnosis of psychiatric disorders and the development of innovative therapies to help our clients make breakthroughs in this area.

Overview of Functional Genomics Research Services for Psychiatric Disorders

Ace Therapeutics employs our functional genomics platform to help our clients research the genetic mechanisms of psychiatric disorders. Our research strategy focuses on the following areas:

• Integration of multidimensional data: Our team of experts combines DNA variation and RNA expression data with cell biology, neuroimaging, cognitive science, and clinical manifestations to reveal associations between genotypes, expression patterns, and disease phenotypes.
• Building genotype-expression-phenotype models: By discovering how specific genetic variants affect RNA splicing and expression, we build molecular models that reflect the relationship between genetic risk and disease state, providing testable hypotheses for subsequent studies.
• Identification of key isoforms: We focus on RNA isoforms that are strongly associated with disease risk, and identify the isoforms that are most likely to affect the disease process by analyzing the association of DNA clinical risk variants with specific RNA splice variants.
• Design of gene expression manipulation models: Based on the above findings, we develop in vitro cellular models and in vivo animal models to study alterations in brain function through gene expression manipulation to gain insights into the biological basis of psychiatric disorders.
• Exploring functional consequences and therapeutic targets: We document biochemical, electrophysiological, transcriptomic, and behavioral changes caused by different risk genes to construct a comprehensive catalog of consequences, which provides a scientific basis and pathway guidance for finding molecular targets for therapeutic interventions.
• Facilitating therapeutic interventions: by understanding key pathways, our research provides important clues for the development of therapeutic strategies targeting psychiatric disorders, accelerating the translational process from basic research to clinical application.

Our Technologies and Methods

• High-throughput sequencing technologies (e.g. Illumina, PacBio)
• Gene editing technologies (e.g., CRISPR-Cas9)
• Single-cell sequencing technologies
• Neuroimaging technologies
• Animal models of psychiatric disorders

Our Service Features

• Individualization: Customized research solutions based on clients' demands.
• Interdisciplinary team: We combine the knowledge of experts in genetics, molecular biology, neuroscience, and other disciplines, we provide an interdisciplinary and comprehensive research perspective.
• Cutting-edge technologies: Latest genomics and bioinformatics technology to ensure the timeliness and scientific accuracy of the research.

Ace Therapeutics provides functional genomics services to help clients systematically explore the genetic mechanisms behind psychiatric disorders and provide precise scientific guidance for disease prevention, diagnosis, and treatment. Please contact us for more details. Our dedicated project team looks forward to working with you to accelerate the success of your psychiatric disorders research program.