Zebrafish Psoriasis Model Development Services

Psoriasis pathogenesis involves complex interactions between genetic factors and environmental triggers, often posing challenges in developing effective therapies. At Ace Therapeutics, we offer specialized services by developing and validating zebrafish models tailored for psoriasis research.

Overview of Zebrafish Models in Psoriasis Research

Zebrafish (Danio rerio) are increasingly recognized for their utility in biomedical research due to their genetic, anatomical, and physiological similarities to humans. Their rapid developmental cycle, transparent embryos, and the ability to conduct real-time imaging make them an ideal model for studying psoriasis. Studies have shown that zebrafish share approximately 70% of their genetic makeup with humans and possess orthologs for around 80% of genes associated with human diseases, including those relevant to psoriasis.

The use of zebrafish in psoriasis research enables the exploration of inflammatory pathways and immune responses. Researchers can induce psoriatic-like conditions in zebrafish through the administration of inflammatory cytokines or by genetic manipulation, allowing for the observation of disease progression in a living organism. For example, zebrafish models have been developed to mimic key features of psoriasis, such as skin lesions and immune cell infiltration, providing a robust platform for preclinical testing of new therapies.

Fig. 1 Zebrafish allows the detailed in vivo study of the effect of key molecules and cells related to psoriasis. (Martínez-Navarro FJ, et al., 2019)

Comprehensive Zebrafish Psoriasis Model Development Services

At Ace Therapeutics, we offer a comprehensive suite of services focused on the development and validation of zebrafish models for psoriasis research.

Custom Model Development

• Genetic Manipulation: Using genetically modified zebrafish to study the function of specific genes and proteins involved in psoriasis progression.
• Induction of Psoriatic Phenotypes: Employing pharmacological agents or cytokines to induce inflammation and hyperproliferation in zebrafish, mimicking the clinical manifestations of psoriasis.

Model Validation

• Phenotypic Characterization: Comprehensive analysis of skin morphology, immune cell infiltration, and keratinocyte proliferation using histological techniques and imaging assays.
• Molecular Assays: Assessing the expression of key inflammatory markers and cytokines through quantitative PCR and immunohistochemistry, confirming the presence of psoriatic-like features.

Advanced Imaging Services

• Live Animal Imaging: Utilizing fluorescent markers to visualize cellular processes in live zebrafish embryos, allowing for the observation of drug effects on inflammation and tissue development.
• Automated Imaging Systems: Implementing high-throughput imaging systems to capture detailed morphological and behavioral data, enhancing the analysis of drug responses.

Zebrafish models represent a valuable tool in the study of psoriasis, enabling researchers to gain insights into disease mechanisms and evaluate potential therapies efficiently. Ace Therapeutics is committed to providing high-quality zebrafish model development and validation services. Contact us today to learn how we can support your research.