Topical Antipsoriatic Drug Development Services

For mild to moderate psoriasis, topical drugs are often preferred due to their localized action and reduced risk of systemic side effects. At Ace Therapeutics, our expertise in preclinical research and development provides the solution for advancing topical antipsoriatic therapies.

Introduction to Topical Antipsoriatic Drugs

Topical therapies remain the first-line treatment for psoriasis due to their targeted action and reduced systemic exposure. These formulations primarily include corticosteroids, vitamin D analogs, retinoids, and novel therapies such as biologics. The effectiveness of these agents is often limited by their ability to penetrate the skin barrier, necessitating advanced drug delivery systems.

Recent advancements have focused on utilizing nanotechnology to improve the bioavailability of active ingredients. Liposomes, solid lipid nanoparticles, and polymeric micelles are some of the innovative systems that enhance skin penetration and localized drug delivery. For instance, studies have shown that liposomal formulations can significantly increase the permeation of corticosteroids through the stratum corneum, leading to improved therapeutic outcomes.

Fig. 1 Schematic illustration of anatomical structure of the human skin and representative novel drug delivery system for the topical treatment of psoriasis. (An P, et al., 2024)

Comprehensive Topical Antipsoriatic Drug Development Services

Ace Therapeutics offers a full spectrum of preclinical services tailored to the development of topical antipsoriatic drugs. Our services encompass every preclinical stage of the drug development pipeline, ensuring a streamlined process from concept to preclinical validation.

Customized Formulation Development

Our team sssissts in designing and formulating innovative topical therapies utilizing various drug delivery systems. Ace Therapeutics specializes in the screening of advanced topical drug delivery systems tailored to enhance the efficacy of antipsoriatic agents.

Comprehensive Analytical Services

We provide comprehensive analytical services that include stability testing, release kinetics, and characterization of the physicochemical properties of formulations. These analyses are crucial for understanding how your samples behave in various environments and evaluating their viability for further development.

In-Depth Preclinical Testing

Preclinical testing is crucial for assessing the safety and efficacy of topical formulations before advancing to further stages of development.

• In Vitro Skin Permeation Studies: Utilizing Franz diffusion cells to evaluate the permeation characteristics of formulations through skin models. This allows our clients to quantify the enhancement in drug delivery achieved by our innovative systems.
• In Vivo Efficacy Models: Implementing animal models to assess the therapeutic effects of formulations on psoriasis-like conditions. Our services focus on key parameters such as reduction in lesion severity and inflammatory marker levels, providing robust data for the effectiveness of our drug delivery systems.

Our Advantages in Topical Antipsoriatic Drug Development

• Expertise in Drug Delivery Systems: We help clients optimize the delivery of their antipsoriatic drug candidates through our expertise in advanced drug delivery systems, including nanotechnology-based approaches.
• Commitment to Cutting-Edge Research: Our team continuously monitors and integrates the latest scientific literature, emerging technologies, and market trends to ensure our formulations reflect the most advanced approaches.
• Stringent Quality Control: Our dedicated quality control team meticulously monitors every step of the process, from formulation development to final product testing.

Ace Therapeutics is dedicated to advancing the development of topical antipsoriatic drugs through comprehensive formulation strategies, rigorous preclinical testing, and a commitment to quality. Contact us today to learn more about how we can support your drug development journey and help you achieve success in the competitive field of psoriasis therapeutics.