Preclinical Pharmacokinetic Services for Antipsoriatic Drug Development

studies are essential to gain this crucial insight. At Ace Therapeutics, we offer a comprehensive suite of preclinical PK services designed to accelerate the development of innovative antipsoriatic therapies.

The Importance of Pharmacokinetic Study in Antipsoriatic Drug Development

Pharmacokinetics encompasses the study of drug absorption, distribution, metabolism, and elimination (ADME). Understanding these processes is crucial for optimizing drug efficacy, ensuring safety, and predicting potential drug-drug interactions.

• Optimizing Drug Formulation and Delivery: Pharmacokinetic studies play a crucial role in the design and optimization of formulations of antipsoriatic agents. For instance, specific excipients in topical formulations can be tailored based on PK data to improve drug penetration through the skin barrier.
• Dose-Response Relationships: Pharmacokinetic studies establish dose-response relationships used to determine effective dosing regimens. For example, the profiles of monoclonal antibodies such as secukinumab and ixekizumab have shown a direct correlation between drug concentration and clinical efficacy in psoriasis models.
• Predicting Drug Interactions: Understanding pharmacokinetics allows researchers to identify potential drug-drug interactions. Comprehensive PK studies help evaluate how antipsoriatic agents may interact with other medications which can affect efficacy and safety.

Fig. 1 Schematic of the minimal physiologically-based pharmacokinetic (mPBPK) model for secukinumab and ixekizumab incorporating IL-17 binding in serum and skin. (Ayyar VS, et al., 2022)

Comprehensive Preclinical Pharmacokinetic Services for Antipsoriatic Drug Development

Ace Therapeutics offers a comprehensive suite of PK services designed to support the development of safe and effective antipsoriatic drugs. Our expertise lies in understanding how antipsoriatic drugs interact with the skin and the systemic circulation, providing valuable insights for optimizing efficacy and safety.

Dermato-pharmacokinetic Services

Topical treatments are the cornerstone of antipsoriatic therapy. Ace Therapeutics offers specialized dermato-pharmacokinetic services to evaluate how these drugs are absorbed and distributed within the skin layers.

• Skin Penetration and Retention Studies: Our studies focus on quantifying drug levels in different skin layers, from the stratum corneum to the deeper dermis. We use dermal microdialysis and tape-stripping techniques to assess drug concentration profiles.
• Topical Formulation Optimization: By evaluating the rate of absorption and retention within the skin, we can guide the optimization of topical formulations to ensure that they deliver effective concentrations at the site of action.

Systemic Pharmacokinetic Services

Systemic pharmacokinetic services are essential for understanding the behavior of drugs that enter the bloodstream after topical or oral administration. Ace Therapeutics conducts detailed studies to evaluate the systemic exposure of the drug candidates and their distribution throughout the body.

• In Vivo PK Studies: Our in vivo studies involve administering the drug to animal models and analyzing its absorption, distribution, metabolism, and excretion. Blood sampling and tissue analysis are used to track drug levels over time.
• Distribution Studies: We provide insights into how the drug is distributed among various organs and tissues, which is critical to ensuring that the drug reaches its intended site of action without causing off-target effects.

Bioavailability Assessment

Bioavailability is a key parameter in pharmacokinetics, representing the extent and rate at which a drug becomes available at the site of action. For antipsoriatic drugs, particularly those administered topically, understanding bioavailability is crucial for optimizing therapeutic efficacy.

• Quantitative Bioavailability Studies: Ace Therapeutics employs high-performance liquid chromatography (HPLC) and mass spectrometry (MS) to measure drug concentrations in plasma and tissue samples, providing precise data on the bioavailability for both topical and systemic formulations.
• Comparative Formulation Analysis: We assess the bioavailability of different drug formulations to help our clients determine which formulation is more effective in maximizing therapeutic benefits.

PK/PD Analysis

Pharmacokinetic/pharmacodynamic (PK/PD) analysis is vital for linking drug exposure to therapeutic effect. At Ace Therapeutics, our PK/PD studies are designed to optimize dosing regimens by correlating drug concentration levels with biological responses.

• Dose-Response Studies: We provide dose-response study services to assist clients in determining the optimal dosing of antipsoriatic drugs to ensure effective treatment while maintaining safety limits.
• Mechanistic PK/PD Modeling: Using advanced modeling techniques, we predict how changes in drug dosage or formulation affect the pharmacodynamic outcomes, providing valuable insights into how to maximize drug efficacy and minimize side effects.

Ace Therapeutics is committed to supporting the development of innovative and effective antipsoriatic therapies. Our comprehensive PK services enable our clients to make informed decisions and advance their research programs with confidence. Contact us today to learn more about our services and how we can help you achieve your research objectives.