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Drug Development Services for Plaque Psoriasis

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At Ace Therapeutics, we specialize in providing comprehensive drug development services tailored specifically for plaque psoriasis, a chronic inflammatory skin disorder that affects millions worldwide.

Pathophysiology of Plaque Psoriasis

Plaque psoriasis results from a complex interplay between genetic predisposition and environmental triggers, leading to immune dysregulation. The disease is marked by the infiltration of T cells and the production of pro-inflammatory cytokines such as interleukin (IL)-17 and tumor necrosis factor (TNF). These factors drive keratinocyte proliferation, resulting in the formation of characteristic plaques. The pathophysiological mechanism involves the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways, which play critical roles in mediating inflammatory responses.

Fig 1. Description of the pathophysiology of plaque psoriasis. Fig. 1 Depiction of pathophysiology of plaque psoriasis. (Priyanka Jurel, et al., 2024)

Comprehensive Drug Development Services for Plaque Psoriasis

Ace Therapeutics provides end-to-end drug development solutions, tailored to address the complexities of plaque psoriasis. Our services encompass a wide range of preclinical studies designed to streamline the drug discovery process.

Items	Service Detail
Target Identification and Validation	Utilization of genomic and proteomic techniques to discover novel therapeutic targets. Validation of targets through in vitro assays to confirm their role in disease mechanisms.
Pharmacology Studies	In vitro evaluation of drug candidates to assess their efficacy against specific psoriasis-related pathways. In vivo studies utilizing appropriate animal models to determine pharmacokinetics and pharmacodynamics.
Toxicology Studies	Comprehensive toxicological assessments to evaluate safety profiles of novel antipsoriatic drugs. Identification of potential adverse effects and dose-limiting toxicities.
Formulation Development	Development of optimized formulations for various delivery methods (topical, systemic). Focus on enhancing bioavailability and stability of active pharmaceutical ingredients.
Bioanalytical Services	Implementation of bioanalytical methods for quantifying drug levels in biological matrices. Application of LC-MS/MS and other advanced techniques to ensure accurate data.

Our Advantages in Drug Development Services for Plaque Psoriasis

Expertise in Dermatological Research: Our team's extensive experience in dermatological research assist in addressing the specific challenges associated with developing therapies for skin conditions. This expertise translates into a deeper understanding of the disease mechanisms and the nuances of effective therapeutic strategies.
State-of-the-Art Facilities: We are equipped with state-of-the-art laboratories that facilitate advanced research methodologies, including high-throughput screening, in vivo modeling psoriasis, and biopharmaceutical characterization of antipsoriatic therapeutics.
Customized Solutions: We work closely with our clients to understand their unique goals and challenges. This ensures that our services are customized to meet the specific needs of each project, facilitating a more effective and efficient development process.

The development of effective treatments for plaque psoriasis requires a multifaceted approach that combines scientific expertise, innovative technologies, and rigorous data analysis. At Ace Therapeutics, our comprehensive drug development services are designed to meet the unique challenges of this complex disease. Contact us today to learn more about how we can support your drug development journey.

Reference

Priyanka Jurel, et al. Treatment of chronic plaque psoriasis: An overview on current update. Pharmacological Research - Reports. Volume 2,2024.100004.

All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.