Antipsoriatic Peptide Development Services

Peptide-based therapeutics offer a promising alternative for the treatment of psoriasis due to their specific mechanisms of action and potential for fewer adverse effects. Ace Therapeutics focuses on providing comprehensive preclinical development services tailored for antipsoriatic peptide development, offering expertise from discovery to in vivo validation.

Introduction to Antipsoriatic Peptides

Antipsoriatic peptides are short chains of amino acids that exhibit significant therapeutic potential against psoriasis. They act primarily by modulating immune responses, inhibiting inflammatory pathways, and promoting skin homeostasis. Recent studies, including research utilizing phage display technology, have successfully identified peptides that can antagonize the effects of IFN-α, thereby reducing inflammation and keratinocyte hyperproliferation. One of these studies demonstrated the efficacy of a peptide, Pep3D, which significantly reduced skin lesions in murine models. This peptide not only decreased lesion severity but also reduced inflammatory cell infiltration and the production of pro-inflammatory cytokines such as IL-17A and TNFα. The identification of these peptides highlights the potential for targeted therapeutic strategies in managing psoriasis.

Fig. 1 Anti-psoriatic effect of Phpep3D assayed in the IMQ-induced psoriasis murine model, and blocking assay of IFNα activity. (Zapi-Colín LA, et al., 2020)

Comprehensive Antipsoriatic Peptide Development Services

At Ace Therapeutics, we provide a full suite of preclinical services dedicated to the development of antipsoriatic peptides. Our approach encompasses every stage of peptide development, from initial design to preclinical evaluation.

Antipsoriatic Peptide Screening and Identification

We utilize high-throughput screening methods with phage display libraries to identify peptides with specific anti-psoriatic activity.

• Biopanning: Multiple rounds of biopanning are performed to enrich peptide candidates that selectively bind to targets associated with psoriasis, such as immune receptors or inflammatory mediators.
• Sequencing: Selected phage clones are sequenced to determine the amino acid sequences of the most promising peptides.

Antipsoriatic Peptide Synthesis and Optimization

• Solid-Phase Peptide Synthesis (SPPS): We employ SPPS to synthesize high-purity peptides, allowing for precise control over peptide sequence and modifications.
• Modification Strategies: Peptides can be customized through chemical modifications based on customer requirements, including cyclization or conjugation to carrier proteins, aiming to enhance stability and potency.

In Vitro Characterization of Antipsoriatic Peptides

• Cytokine Production: Evaluation of the effect of peptides on the secretion of pro-inflammatory cytokines (e.g., IL-17A, TNF-α).
• Cell Proliferation: Using MTT or BrdU assays to measure the effects of antipsoriatic peptides on keratinocyte growth and proliferation.

In Vivo Efficacy Testing of Antipsoriatic Peptides

• Murine Models: Our team conducts in vivo studies using animal models of psoriasis, such as imiquimod (IMQ) models.
• Histopathological Analysis: We collect skin samples and analyze histological changes, including inflammation, keratinocyte proliferation, and immune cell infiltration.

Antipsoriatic Peptide Formulation and Delivery Optimization

• Stability Enhancement: We employ various strategies, including peptide modifications, to improve peptide half-life, stability, and tissue penetration.
• Formulation Development: We develop optimal delivery methods for antipsoriatic peptides, including topical gels, injectables, and oral formulations.

Our Advantages in Antipsoriatic Peptide Development

• Expertise in Immunology and Peptide Chemistry: Our team comprises experts with deep knowledge in immunology, molecular biology, and peptide chemistry, ensuring scientifically rigorous development processes.
• Proven Methodologies: We employ established techniques such as phage display, high-throughput screening, and validated in vivo models to provide reliable and reproducible data.
• Customizable Service Options: We offer flexible service options tailored to meet the specific needs of each client, making our development pathways highly customizable.

Ace Therapeutics is dedicated to advancing peptide-based therapeutics for psoriasis. By partnering with us, clients gain access to unparalleled expertise and comprehensive preclinical development services. Contact us today to discuss how we can support your antipsoriatic peptide development projects.