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* Services of Interest: Customized Rabbit Models of Retinal Detachment
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* All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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Customized Rabbit Models of Retinal Detachment

Retinal detachment (RD), a separation of the neurosensory retina from the retinal pigment epithelium (RPE), is a serious ophthalmological disease leading to photoreceptor cell death and potentially irreversible vision loss. Preclinical research relies heavily on animal models to elucidate the pathophysiological mechanisms of RD and evaluate novel therapeutic interventions. At Ace Therapeutics, we specialize in developing customized rabbit models of retinal detachment, leveraging our expertise in preclinical research to provide invaluable tools for the investigation of RD.

Overview of Retinal Detachment and Related Rabbit Models

Retinal detachment occurs when the retina separates from the underlying RPE, disrupting its metabolic support and leading to photoreceptor cell death. This disease can be classified into three main types: rhegmatogenous, tractional, and exudative. Rhegmatogenous RD, the most common form, is often caused by retinal breaks due to vitreoretinal traction or other factors. Tractional RD occurs due to mechanical forces pulling the retina away, while exudative RD results from fluid accumulation beneath the retina without breaks.

Rabbit models are particularly advantageous for studying RD due to their anatomical and physiological similarities to human eyes. Various methods, including the injection of hyaluronidase, can induce retinal detachment in these models, providing insights into the dynamics of the condition and potential treatment modalities.

Fig 1. The three primary types of retinal detachment. Fig. 1. The three major forms of retinal detachment. (Zhang ZY, et al., 2021)

Service Overview

Ace Therapeutics provides comprehensive services in developing customized rabbit models of retinal detachment. Our expertise allows us to tailor the models to specific research needs, whether investigating the underlying mechanisms of RD or testing new therapeutics.

Explore Ace Therapeutics' Rodent Models of Retinal Detachment

Recognizing the diverse needs of RD research, Ace Therapeutics offers customized model development services. Our services encompass the entire process, from model development to comprehensive evaluation, enabling researchers to explore the mechanisms of RD and assess potential therapeutics. By utilizing techniques such as hyaluronidase injection, we develop reliable models that recapitulate the conditions of retinal detachment.

Exudative Retinal Detachment (ERD) Model
We induce ERD through precise subretinal injections of substances such as sodium hyaluronate. The concentration and volume of the injectate are carefully calibrated to control the extent and duration of the detachment, supporting researchers to investigate the early and late stages of ERD. Ace Therapeutics' meticulous surgical techniques minimize variability and ensure consistent, reproducible results.
Rhegmatogenous Retinal Detachment (RRD) Model
We develop RRD models to replicate the most common type of RD, characterized by retinal breaks. We employ a refined method of hyaluronidase-induced detachment. Hyaluronidase, injected into the vitreous cavity, degrades hyaluronic acid, causing rapid vitreous liquefaction. Coupled with controlled aspiration, this process induces retinal tears, faithfully mimicking the clinical presentation of RRD. Ace Therapeutics provides a comprehensive platform to study the mechanisms of retinal tearing and evaluate interventions aimed at promoting retinal reattachment.

Comprehensive Monitoring and Evaluation of Retinal Detachment Models

Optical Coherence Tomography (OCT): We utilize high-resolution OCT to monitor retinal thickness and morphology, providing detailed structural information about the detachment and its response to treatment.
Electroretinography (ERG): We utilize ERG to assess retinal function by measuring the electrical responses of the retina to light stimuli. This provides critical insights into the functional consequences of RD and the potential of therapeutic agents to preserve retinal function.
Histological Analysis: We perform detailed histological analyses, including H&E and TUNEL staining, to evaluate cellular changes within the retina. This allows for precise quantification of photoreceptor cell death and other pathological changes associated with RD.

Ace Therapeutics is committed to providing high-quality, customizable RD models and comprehensive analytical services. By offering tailored induction protocols, comprehensive evaluation techniques, and expert support, we empower researchers to explore the complex mechanisms of RD and evaluate innovative therapeutic strategies. For more information or to discuss your specific research needs, please do not hesitate to contact us.

Reference

Zhang ZY, et al. Experimental models and examination methods of retinal detachment. Brain Res Bull. 2021;169:51-62.

For Research Use Only.