Yangambin

Cat. No.: IBDI-430853

Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca 2+ influx through voltage-gated Ca 2+ channels, leading to the reduction in [Ca 2+]i in vascular smooth muscle cells and consequent peripheral vasodilation. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM.

Product Details

Target	Calcium Channel
Molecular Weight	446.49
Appearance	Solid
SMILES	COC1=C(OC)C(OC)=CC([[email protected]]2OC[[email protected]]3([H])[[email protected]@H](C4=CC(OC)=C(OC)C(OC)=C4)OC[[email protected]@]32[H])=C1
Structure Classification	Phenylpropanoids>Lignans
Purity	≥98.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.