Cat. No.: IBDP-531243
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Online InquiryTarget Information
| Sequence | MRKNPKAGVP ALQKAGNCPP LEDNTVRVDI RIFNQNQGIS VPREFQNRSS SPWDYNITRD PHRFPSEIAE AQCRHSGCIN AQGQEDSTMN SVAIQQEILV LRREPQGCSN SFRLEKMLLK VGCTCVKPIV HQAA |
| Sequence Similarities | Belongs to the IL-17 family. |
| Amino Acids | 29 to 161 |
| Cellular Localization | Secreted. |
| Tissue Specificity | Expressed in activated, but not resting, CD4+ T-cells and activated monocytes. |
| Function | Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation. |
Product Details
| Product Type | Protein |
| Species | Mouse |
| Source | E. coli |
| Endotoxin Level | <0.05 Eu/µg |
| Protein Length | Full length protein |
| Molecular Weight | 30 kDa |
| Purity | >95% |
| Active | Yes |
| Animal free | Yes |
| Nature | Recombinant |
| Application | FuncS, SDS-PAGE |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at -20 °C or -80 °C. |
| Handling | Avoid freeze / thaw cycle. |