Recombinant Mouse IKK beta Protein

Target Information

Sequence	MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQEL SPKNRNRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQ GGDLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENRIIHRDLKPEN IVLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYT VTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLN GAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCF RALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETD QELLQKAGLVLLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQ ITPRPPPESVSCILQEPKRNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQG QRAAMMSLLRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYKEQ TEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMALQTDIVDLQRS PMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQS FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKR QKELWNLLKIAC
Sequence Similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. Contains 1 protein kinase domain.
Amino Acids	1 to 662
Cellular Localization	Cytoplasm. Membrane raft. Colocalized with DPP4 in membrane rafts.
Tissue Specificity	Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
Function	Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.

Product Details

Product Type	Protein
Species	Mouse
Source	Baculovirus Infected Sf9 Cells
Tag	GST
Protein Length	Protein fragment
Purity	>85%
Active	Yes
Animal free	No
Nature	Recombinant
Application	FuncS, SDS-PAGE

Storage & Handling

Shipping	Shipped with Dry Ice.
Storage	Store at -20 °C or -80 °C.
Handling	Avoid freeze / thaw cycle.