Recombinant Mouse FLT1/VEGF Receptor 1 Protein

Target Information

Sequence	YGSGSKLKVPELSLKGTQHVMQAGQTLFLKCRGEAAHSWSLPTTVSQEDK RLSITPPSACGRDNRQFCSTLTLDTAQANHTGLYTCRYLPTSTSKKKKAE SSIYIFVSDAGSPFIEMHTDIPKLVHMTEGRQLIIPCRVTSPNVTVTLKK FPFDTLTPDGQRITWDSRRGFIIANATYKEIGLLNCEATVNGHLYQTNYL THRQTNTILDVQIRPPSPVRLLHGQTLVLNCTATTELNTRVQMSWNYPGK ATKRASIRQRIDRSHSHNNVFHSVLKINNVESRDKGLYTCRVKSGSSFQS FNTSVHVYEKGFISVKHRKQPVQETTAGRRSYRLSMKVKAFPSPEIVWLK DGSPATLKSARYLVHGYSLIIKDVTTEDAGDYTILLGIKQSRLFKNLTAT LIVNVKPQIYEKSVSSLPSPPLYPLGSRQVLTCTVYGIPRPTITWLWHPC HHNHSKERYDFCTENEESFILDPSSNLGNRIESISQRMTVIEGTNKTVST LVVADSQTPGIYSCRAFNKIGTVERNIKFYVTDVPNGFHVSLEKMPAEGE DLKLSCVVNKFLYRDITWILLRTVNNRTMHHSISKQKMATTQDYSITLNL VIKNVSLEDSGTYACRARNIYTGEDILRKTEVLVRDSEAPHLLQNLSDYE VSISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGIILGPGNSTLFIERV TEEDEGVYRCRATNQKGAVESAAYLTVQGTSDKSNLE
Sequence Similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.
Amino Acids	23 to 759
Cellular Localization	Secreted and Cell membrane.
Tissue Specificity	Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform sFlt1 is strongly expressed in placenta.
Function	Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Product Details

Product Type	Protein
Species	Mouse
Source	HEK 293 Cells
Endotoxin Level	≤0.005 Eu/µg
Protein Length	Protein fragment
Molecular Weight	83 kDa
Purity	≥95%
Active	Yes
Animal free	Yes
Nature	Recombinant
Application	SDS-PAGE

Storage & Handling

Shipping	Shipped at Room Temperature.
Storage	Store at Room Temperature.
Handling	Avoid freeze / thaw cycle.