Recombinant Human NLRP3 Protein

Target Information

Sequence	KDYRKKYRKY VRSRFQCIED RNARLGESVS LNKRYTRLRL IKEHRSQQER EQELLAIGKT KTCESPVSPI KMELLFDPDD EHSEPVHTVV FQGAAGIGKT ILARKMMLDW ASGTLYQDRF DYLFYIHCRE VSLVTQRSLG DLIMSCCPDP NPPIHKIVRK PSRILFLMDG FDELQGAFDE HIGPLCTDWQ KAERGDILLS SLIRKKLLPE ASLLITTRPV ALEKLQHLLD HPRHVEILGF SEAKRKEYFF KYFSDEAQAR AAFSLIQENE VLFTMCFIPL VCWIVCTGLK QQMESGKSLA QTSKTTTAVY VFFLSSLLQP RGGSQEHGLC AHLWGLCSLA ADGIWNQKIL FEESDLRNHG LQKADVSAFL RMNLFQKEVD CEKFYSFIHM TFQEFFAAMY YLLEEEKEGR TNVPGSRLKL PSRDVTVLLE NYGKFEKGYL IFVVRFLFGL VNQERTSYLE KKLSCKISQQ IRLELLKWIE VKAKAKKLQI QPSQLELFYC LYEMQEEDFV QRAMDYFPKI EINLSTRMDH MVSSFCIENC HRVESLSLGF LHNMPKEEEE EEKEGRHLDM VQCVLPSSSH AACSHGLVNS HLTSSFCRGL FSVLSTSQSL TELDLSDNSL GDPGMRVLCE TLQHPGCNIR RLWLGRCGLS HECCFDISLV LSSNQKLVEL DLSDNALGDF GIRLLCVGLK HLLCNLKKLW LVSCCLTSAC CQDLASVLST SHSLTRLYVG ENALGDSGVA ILCEKAKNPQ CNLQKLGLVN SGLTSVCCSA LSSVLSTNQN LTHLYLRGNT LGDKGIKLLC EGLLHPDCKL QVLELDNCNL TSHCCWDLST LLTSSQSLRK LSLGNNDLGD LGVMMFCEVL KQQSCLLQNL GLSEMYFNYE TKSALETLQE EKPELTVVFE PSW
Sequence Similarities	Belongs to the NLRP family. Contains 1 DAPIN domain. Contains 9 LRR (leucine-rich) repeats. Contains 1 NACHT domain.
Amino Acids	134 to 1036
Cellular Localization	Cytoplasm.
Tissue Specificity	Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells and osteoblasts. Undetectable or expressed at a lower magnitude in B- and T-lymphoblasts, respectively. High level of expression detected in chondrocytes. Detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder.
Function	May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.

Product Details

Product Type	Protein
Species	Human
Source	HEK 293 Cells
Tag	DDDDK Tag
Protein Length	Protein fragment
Molecular Weight	105 kDa
Purity	>75%
Active	No
Animal free	No
Nature	Recombinant
Application	SDS-PAGE

Storage & Handling

Shipping	Shipped with Dry Ice.
Storage	Store at -80 °C.
Handling	Avoid freeze / thaw cycle.