Recombinant Human IRAK4 Protein

Target Information

Sequence	AVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSP ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKG YVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSS DGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLH ENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTA YMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEI EDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQL LQEMTAS
Sequence Similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Contains 1 death domain. Contains 1 protein kinase domain.
Amino Acids	104 to 460
Function	Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1.

Product Details

Product Type	Protein
Species	Human
Source	Insect Cells
Tag	GST
Protein Length	Protein fragment
Molecular Weight	52 kDa
Purity	>80%
Active	Yes
Animal free	No
Nature	Recombinant
Application	FuncS, SDS-PAGE, WB

Storage & Handling

Shipping	Shipped with Dry Ice.
Storage	Store at -20 °C or -80 °C.
Handling	Avoid freeze / thaw cycle.