Recombinant Human IRAK-1 Protein

Target Information

Sequence	SVSLLQGARP FPFCWPLCEI SRGTHNFSEE LKIGEGGFGC VYRAVMRNTV YAVKRLKENA DLEWTAVKQS FLTEVEQLSR FRHPNIVDFA GYCAQNGFYC LVYGFLPNGS LEDRLHCQTQ ACPPLSWPQR LDILLGTARA IQFLHQDSPS LIHGDIKSSN VLLDERLTPK LGDFGLARFS RFAGSSPSQS SMVARTQTVR GTLAYLPEEY IKTGRLAVDT DTFSFGVVVL ETLAGQRAVK THGARTKYLK DLVEEEAEEA GVALRSTQST LQAGLAADAW AAPIAMQIYK KHLDPRPGPC PPELGLGLGQ LACCCLHRRA KRRPPMTQVY ERLEKLQAVV AGVPG
Sequence Similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Contains 1 protein kinase domain.
Amino Acids	186 to 530
Tissue Specificity	Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.
Function	Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.

Product Details

Product Type	Protein
Species	Human
Source	Baculovirus Infected Sf9 Cells
Tag	His
Protein Length	Protein fragment
Molecular Weight	40 kDa
Purity	≥90%
Active	Yes
Animal free	No
Nature	Recombinant
Application	FuncS, SDS-PAGE

Storage & Handling

Shipping	Shipped with Dry Ice.
Storage	Store at -80 °C.
Handling	Avoid freeze / thaw cycle.