Recombinant Human IKB alpha Protein

Target Information

Sequence	MGSSHHHHHHSSGLVPRGSHMFQAAERPQEWAMEGPRDGLKKERLLDDRH DSGLDSMKDEEYEQMVKE LQEIRLEPQEVPRGSEPWKQQLTEDGDSFL HLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQ PEI AEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSIL KATNYNGHTCLHLASIHGYLGI VELLVSLGADVNAQEPCNGRTALHLA VDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLT LENLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL
Sequence Similarities	Belongs to the NF-kappa-B inhibitor family. Contains 5 ANK repeats.
Amino Acids	1 to 317
Cellular Localization	Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Product Details

Product Type	Protein
Species	Human
Source	E. coli
Tag	His
Protein Length	Full length protein
Molecular Weight	38 kDa
Purity	>90%
Active	No
Animal free	No
Nature	Recombinant
Application	MS, SDS-PAGE

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20 °C.
Handling	Avoid freeze / thaw cycle.