Cat. No.: IBDP-531651
Size:
Online InquiryTarget Information
| Sequence Similarities | Belongs to the NF-kappa-B inhibitor family. Contains 5 ANK repeats. |
| Amino Acids | 1 to 317 |
| Cellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
Product Details
| Product Type | Protein |
| Species | Human |
| Source | E. coli |
| Tag | GST |
| Protein Length | Full length protein |
| Molecular Weight | 60 kDa |
| Purity | >80% |
| Active | No |
| Animal free | No |
| Nature | Recombinant |
| Application | SDS-PAGE, WB |
Storage & Handling
| Shipping | Shipped with Dry Ice. |
| Storage | Store at -20 °C or -80 °C. |
| Handling | Avoid freeze / thaw cycle. |