Recombinant Human C5 (mutated W917S) Protein

Target Information

Sequence Similarities	Contains 1 anaphylatoxin-like domain. Contains 1 NTR domain.
Amino Acids	19 to 1676
Cellular Localization	Secreted.
Function	Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).

Product Details

Product Type	Protein
Species	Human
Source	HEK 293 Cells
Tag	His
Modifications	mutated W917S
Endotoxin Level	<1.0 Eu/µg
Protein Length	Full length protein
Molecular Weight	188 kDa
Purity	>95%
Active	Yes
Animal free	No
Nature	Recombinant
Application	FuncS, SDS-PAGE

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -80 °C.
Handling	Avoid freeze / thaw cycle.