Rapamycin

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Cat. No.: IBDI-430220

Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	mTOR \| FKBP \| Fungal \| Autophagy \| Endogenous Metabolite \| Antibiotic \| Bacterial
Molecular Weight	914.17
Appearance	Solid
Synonyms	Sirolimus, AY-22989
SMILES	O=C([[email protected]@]1(O)[[email protected]@H](CC[[email protected]@H](C[[email protected]@H](/C(C)=C/C=C/C=C/[[email protected]](C[[email protected]@H](C)C([[email protected]@H]([[email protected]@H](/C(C)=C/[[email protected]]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[[email protected]]3C(O[[email protected]@H](CC2=O)[[email protected]@H](C[[email protected]]4C[[email protected]]([[email protected]](O)CC4)OC)C)=O)=O
Structure Classification	Antibiotics>Macrolide Antibiotics
Purity	99.94%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.