Cat. No.: IBDAK-620113
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Online InquiryOverview
| Sample Type | Adherent cells, Suspension cells, Nuclear Extracts |
| Detection Method | Colorimetric |
| Assay Type | Semi-quantitative |
| Product Type | Redox Metabolism |
| Species Reactivity | Reacts with: Mouse, Human Predicted to work with: Mammals |
| Platform | Microplate reader |
Target
| Function | Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. |
| Tissue Specificity | Ubiquitous with maximal levels in placenta and skeletal muscle. |
| Sequence Similarities | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Cellular Localization | Nucleus. |
Storage & Handling
| Storage | Store at +4°C. |
| Storage Buffer | Constituent: 100% PBS |