Paris saponin VII

Cat. No.: IBDI-431029

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.

Product Details

Target	Akt | p38 MAPK | P-glycoprotein | Bcl-2 Family | Caspase | PARP | Autophagy | Apoptosis
Molecular Weight	1031.18
Appearance	Solid
Synonyms	Chonglou Saponin VII
SMILES	O[[email protected]@]12[[email protected]@]3([[email protected]@]([[email protected]@]4([H])[[email protected]]([[email protected]@]5(C(C[[email protected]@H](O[[email protected]@]6([H])[[email protected]@H]([[email protected]]([[email protected]](O[[email protected]@]7([H])[[email protected]@H]([[email protected]@H]([[email protected]@H](O[[email protected]@]8([H])[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]](C)O8)O)O)[[email protected]](C)O7)O)O)[[email protected]@H](CO)O6)O)O[[email protected]@]9([H])[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]](C)O9)O)O)CC5)=CC4)C)([H])CC3)([H])C[[email protected]]1([H])O[[email protected]]%10(CC[[email protected]@H](C)CO%10)[[email protected]]2C)C
Structure Classification	Steroids
Purity	99.13%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.