Nonactin

Cat. No.: IBDI-430223

Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K +, and NH4 +. Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin. Nonactin inhibits the surface expression of endogenous HSP60.

Product Details

Target	Potassium Channel | Mitochondrial Metabolism | Bacterial | Influenza Virus | Apoptosis | Antibiotic
Molecular Weight	736.93
Appearance	Solid
Synonyms	Ammonium ionophore I
SMILES	O=C(O[[email protected]](C)C[[email protected]@]1([H])CC[[email protected]@](O1)([H])[[email protected]](C)C(O[[email protected]@H](C)C[[email protected]]2([H])CC[[email protected]](O2)([H])[[email protected]@H](C)C(O[[email protected]](C)C[[email protected]@]3([H])CC[[email protected]@](O3)([H])[[email protected]@H]4C)=O)=O)[[email protected]](C)[[email protected]@](O5)([H])CC[[email protected]@]5([H])C[[email protected]](C)OC4=O
Structure Classification	Antibiotics>Macrolide Antibiotics
Purity	≥99.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.