Cat. No.: IBDAK-620200
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| Sample Type | Tissue Extracts, Cell Lysate |
| Detection Method | Colorimetric |
| Assay Type | Sandwich (quantitative) |
| Assay Time | 1 h 30 min |
| Assay Duration | One step assay |
| Product Type | Chemokines |
| Sensitivity | 0.26 ng/ml |
| Range | 1.25 ng/ml - 80 ng/ml |
| Species Reactivity | Reacts with: Mouse |
| Platform | Pre-coated microplate (12 x 8 well strips) |
Target
| Function | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. |
| Tissue Specificity | Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. |
| Sequence Similarities | Belongs to the Toll-like receptor family. Contains 22 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Contains 1 TIR domain. |
| Cellular Localization | Endoplasmic reticulum membrane. Endosome membrane. |
| Domain | ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18. |
Storage & Handling
| Storage | Store at +4°C. Please refer to protocols. |