Mouse Thioredoxin/TRX Antibody Pair - BSA and Azide free

Overview

Assay Type	ELISA set
Product Type	Redox Metabolism
Species Reactivity	Reacts with: Mouse
Platform	Reagents
Application	Sandwich ELISA

Properties

Carrier Free

Yes

Target

Function	Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
Sequence Similarities	Belongs to the thioredoxin family. Contains 1 thioredoxin domain.
Cellular Localization	Nucleus. Cytoplasm. Secreted. Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.

Storage & Handling

Storage

Store at -20°C. Please refer to protocols.