Mouse EMMPRIN Matched Antibody Pair Kit

Overview

Detection Method	Colorimetric
Assay Type	ELISA set
Product Type	Cell Type Markers
Sensitivity	0.76 pg/ml
Range	7.81 pg/ml - 500 pg/ml
Species Reactivity	Reacts with: Mouse
Platform	Reagents
Application	ELISA, IA

Target

Function	Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
Tissue Specificity	Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
Sequence Similarities	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Cellular Localization	Cell membrane. Melanosome. Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Storage & Handling

Storage	Store at +4°C.
Storage Buffer	Constituent: 100% PBS